Abstract:
:Mast cells are currently recognized as effector cells in many settings beyond just allergic reactions, including innate immunity, autoimmunity, chronic inflammatory disorders and atherosclerosis. Signaling pathways of the mast cell response have been widely explored in the past but these are still linked with single axes, such as the high affinity IgE receptor FcepsilonRI, presumably an exclusive determinant of the magnitude of the response to allergen. By contrast, the T cell receptor is viewed as a rich complex of stimulatory and co-stimulatory molecules, setting an array of thresholds to ensure a highly regulated response. Recent observations show that mast cells express various classes of co-stimulatory molecules that modulate their function. These molecules might therefore contribute to the outcome of mast cell-associated pathologies, and constitute new therapeutic targets in such diseases.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Bachelet I,Levi-Schaffer Fdoi
10.1016/j.it.2007.06.007subject
Has Abstractpub_date
2007-08-01 00:00:00pages
360-5issue
8eissn
1471-4906issn
1471-4981pii
S1471-4906(07)00161-5journal_volume
28pub_type
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journal_title:Trends in immunology
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