Abstract：
:The MHC class II transcriptional activator (CIITA) is the major regulator of expression of MHC class II genes. Thus, CIITA plays a fundamental role in the regulation of the immune response. Here, we discuss our findings on the dual role of CIITA during infections, as the target (prey) for certain pathogens but the host effector (hunter) against other pathogens, including HIV-1. This dual role is placed in an evolutionary context as a rather peculiar example of a strategy used by pathogens to evade host defenses and a counteraction of the host to minimize the survival and spread of the pathogen.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Accolla RS,De Lerma Barbaro A,Mazza S,Casoli C,De Maria A,Tosi Gdoi
10.1016/s1471-4906(01)02003-8keywords:
subject
Has Abstractpub_date
2001-10-01 00:00:00pages
560-3issue
10eissn
1471-4906issn
1471-4981pii
S1471-4906(01)02003-8journal_volume
22pub_type
杂志文章,评审abstract：:Recent studies have reported paradoxical roles of inflammation in tumor immunity triggered by PD-1 checkpoint antibody (Ab) blockade. Here, we elaborate on this controversy and propose a new perspective that might help understand this paradox. Since inflammatory cytokines and PD-1 blockade are known to target differen...
journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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abstract：:Over the years, the role of the eosinophil in asthma and allergic processes has been disputed. Recent human experiments using a humanised monoclonal antibody to interleukin-5 (IL-5), and animal studies involving specific IL-5 gene deletion, indicates that eosinophils might control downstream repair and remodelling pro...
journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
pub_type： 杂志文章
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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doi：10.1016/s1471-4906(02)00014-5
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
pub_type： 新闻
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abstract：:Whether MHC restriction by the T cell receptor (TCR) is a product of evolutionary pressures leading to germline-encoded 'rules of engagement' remains avidly debated. Structural results derived from analysis of TCR-peptide-MHC complexes appear to support a model of physical specificity between TCR germline V regions an...
journal_title：Trends in immunology
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更新日期：2012-09-01 00:00:00
abstract：:The introduction of combined antiretroviral therapies (HAART) has reversed the fatal course of human immunodeficiency virus (HIV) infection. HAART controls virus production and, in most cases, allows the quantitative and functional immune defects caused by HIV to be reversed. Here, we review T cell homeostatic mechani...
journal_title：Trends in immunology
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abstract：:Specific immunotherapy (SIT) is a common treatment for allergic diseases. Despite its usage in clinical practice for nearly a century, more-rational and safer allergen preparations are required. Here, the underlying mechanisms and principles of allergen modification for the future use of SIT in the treatment of allerg...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(01)01862-2
更新日期：2001-04-01 00:00:00
