The Lung Microvasculature Is a Functional Immune Niche.

Abstract:

:Lung capillaries, best known for vital gas exchange, also contribute to neutrophil margination, a phenomenon resulting in large numbers of pulmonary vascular neutrophils. Importantly, the functional relevance of neutrophil margination is unknown. Recent advances in microscopy have altered our understanding of why neutrophils marginate. Specifically, data show that lung capillaries provide a unique anatomical site for neutrophils to capture bloodstream pathogens, which contrasts the conventional monophagocytic-dominated vascular host defense of the spleen and liver. Moreover, lung capillaries provide an efficient site for direct cell-cell communication required for the induction of apoptosis in aged neutrophils. These new ideas transform our views of the pulmonary circulation as a site for immediate neutrophil-mediated host defense and regulation of their life cycle.

journal_name

Trends Immunol

journal_title

Trends in immunology

authors

Granton E,Kim JH,Podstawka J,Yipp BG

doi

10.1016/j.it.2018.09.002

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

890-899

issue

11

eissn

1471-4906

issn

1471-4981

pii

S1471-4906(18)30167-4

journal_volume

39

pub_type

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