Abstract:
:Lung capillaries, best known for vital gas exchange, also contribute to neutrophil margination, a phenomenon resulting in large numbers of pulmonary vascular neutrophils. Importantly, the functional relevance of neutrophil margination is unknown. Recent advances in microscopy have altered our understanding of why neutrophils marginate. Specifically, data show that lung capillaries provide a unique anatomical site for neutrophils to capture bloodstream pathogens, which contrasts the conventional monophagocytic-dominated vascular host defense of the spleen and liver. Moreover, lung capillaries provide an efficient site for direct cell-cell communication required for the induction of apoptosis in aged neutrophils. These new ideas transform our views of the pulmonary circulation as a site for immediate neutrophil-mediated host defense and regulation of their life cycle.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Granton E,Kim JH,Podstawka J,Yipp BGdoi
10.1016/j.it.2018.09.002subject
Has Abstractpub_date
2018-11-01 00:00:00pages
890-899issue
11eissn
1471-4906issn
1471-4981pii
S1471-4906(18)30167-4journal_volume
39pub_type
杂志文章,评审abstract::Detailed sequence analysis of the companion alpha chains in several T-cell receptor (TCR) beta chain transgenic mice have shown that the mature alpha chain repertoires of CD4+ T cells are biased toward the parental TCR alpha chain sequences. These studies further indicate that it is self-peptide-self-MHC recognition d...
journal_title:Trends in immunology
pub_type: 新闻
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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abstract::Non-deletional tolerance resulting in the generation of regulatory T cells within the thymus is a key mechanism for the establishment of immunological self-tolerance. How the high-affinity self-reactive regulatory T cells escape negative selection and what type of antigen-presenting cells positively select them within...
journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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abstract::Chronic viral infections and cancer often lead to the emergence of dysfunctional or 'exhausted' CD8+ T cells, and the restoration of their functions is currently the focus of therapeutic interventions. In this review, we detail recent advances in the annotation of the gene modules and the epigenetic landscape associat...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2017.05.008
更新日期:2017-08-01 00:00:00
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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doi:10.1016/j.it.2020.06.008
更新日期:2020-08-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2003.11.004
更新日期:2004-01-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(03)00026-7
更新日期:2003-03-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2011.01.004
更新日期:2011-04-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2010.12.002
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(02)00029-7
更新日期:2003-02-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2019.01.007
更新日期:2019-03-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2004.07.006
更新日期:2004-09-01 00:00:00
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journal_title:Trends in immunology
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journal_title:Trends in immunology
pub_type: 评论,杂志文章
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
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更新日期:2020-01-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/s1471-4906(02)00014-5
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2015.08.005
更新日期:2015-10-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/s1471-4906(03)00064-4
更新日期:2003-04-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2017.05.003
更新日期:2017-07-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2012.11.001
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journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2006.05.002
更新日期:2006-07-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2016.09.008
更新日期:2016-12-01 00:00:00