Abstract:
:During an immune response, peripheral T-cell populations expand and then contract as the response subsides, thus maintaining a fairly constant number of CD4 and CD8 T cells throughout the life of the individual. The important factors that control this homeostasis are now beginning to be understood. Interleukin-7 (IL-7) has emerged as a central regulator of the survival and homeostasis of CD4 and CD8 T cells. Both naive and memory T-cell populations are highly dependent on the presence of IL-7 for their persistence and survival. In this Review, we discuss the role of IL-7 in the survival and homeostasis of naive and memory T cells and how that role is regulated by other factors.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Bradley LM,Haynes L,Swain SLdoi
10.1016/j.it.2005.01.004keywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
172-6issue
3eissn
1471-4906issn
1471-4981pii
S1471-4906(05)00021-9journal_volume
26pub_type
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更新日期:2016-06-01 00:00:00
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