Abstract：
:The highly polymorphic MHC class Ia molecules have a central role in adaptive immunity. By contrast, the closely related MHC class Ib molecules, which show limited polymorphism, are best known for regulating innate immune responses. Nevertheless, a recent area of interest is the emerging role of class Ib molecules in adaptive immunity, particularly in response to tumours and pathogens such as Mycobacteria, Listeria and Salmonella. Here, we review recent findings in this area, highlighting the structure of a T-cell receptor complexed with a cytomegalovirus peptide bound to the class Ib molecule, HLA-E. Collectively, these findings have implications for immunity, transplantation and autoimmunity, and our understanding of the evolution and plasticity of the molecular interactions mediating adaptive immunity.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Sullivan LC,Hoare HL,McCluskey J,Rossjohn J,Brooks AGdoi
10.1016/j.it.2006.07.006subject
Has Abstractpub_date
2006-09-01 00:00:00pages
413-20issue
9eissn
1471-4906issn
1471-4981pii
S1471-4906(06)00216-Xjournal_volume
27pub_type
杂志文章,评审abstract：:The immune system confines neoplasia at various stages of tumor development. Whereas the role of cellular immunity has been investigated widely and utilized in the clinic, the importance of humoral immunity in this process has begun to emerge only in recent years. Circulating antinuclear autoantibodies (ANAs) typicall...
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abstract：:Neurodegenerative diseases are a group of chronic, progressive disorders characterized by the gradual loss of neurons in discrete areas of the central nervous system (CNS). The mechanism(s) underlying their progressive nature remains unknown but a timely and well-controlled inflammatory reaction is essential for the i...
journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2003-10-01 00:00:00
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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pub_type： 历史文章,杂志文章
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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