Abstract：
:Epstein-Barr Virus (EBV) is one of the most successful human viruses, infecting more than 90% of the adult population worldwide and persisting for the lifetime of the host. Individuals with a history of symptomatic primary EBV infection, called infectious mononucleosis, carry a moderately higher risk of developing multiple sclerosis (MS). In addition, EBV-specific immune responses, which crucially regulate the host-virus balance in healthy virus carriers, are altered in patients with MS. Although no data so far unequivocally support a direct etiologic role of the virus, recent studies allow for the development of testable hypotheses as to how EBV infection potentially promotes autoimmunity and central nervous system (CNS) tissue damage in MS.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Lünemann JD,Münz Cdoi
10.1016/j.it.2009.03.007subject
Has Abstractpub_date
2009-06-01 00:00:00pages
243-8issue
6eissn
1471-4906issn
1471-4981pii
S1471-4906(09)00079-9journal_volume
30pub_type
杂志文章abstract：:Analysis of immunoglobulin (Ig) repertoires aims to comprehend Ig diversity with the goal of predicting humoral immune responses in the context of infection, vaccination, autoimmunity, and malignancies. The first next-generation sequencing (NGS) analyses of bulk B cell populations dramatically advanced sampling depth ...
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journal_title：Trends in immunology
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更新日期：2001-05-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2003.11.004
更新日期：2004-01-01 00:00:00
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journal_title：Trends in immunology
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doi：10.1016/s1471-4906(00)01792-0
更新日期：2001-01-01 00:00:00
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journal_title：Trends in immunology
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doi：10.1016/j.it.2005.03.011
更新日期：2005-06-01 00:00:00
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journal_title：Trends in immunology
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doi：10.1016/s1471-4906(02)00014-5
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更新日期：2016-12-01 00:00:00
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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更新日期：2001-07-01 00:00:00
abstract：:The workshop on Multiple Sclerosis and Chemokines: Prospects for Therapeutic and Prophylactic Intervention was held in Chevy Chase, MD, USA, from 9-10 July 2001. ...
journal_title：Trends in immunology
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doi：10.1016/s1471-4906(01)02056-7
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abstract：:The immune system serves to protect organisms from infectious pathogens. During infection, lymphocytes and cells of the innate immune system, expressing receptors that recognize foreign antigens, proliferate and differentiate to develop effector functions that help to kill the pathogens. Effector functions, such as ce...
journal_title：Trends in immunology
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