Abstract:
:Three recent studies provide new insight into the mechanisms that promote the differentiation of antigen-primed T cells into the follicular helper T (Tfh) lineage, revealing a key role for the transcription factor TCF-1 in the regulation of the Bcl6-Blimp-1 axis that mediates the divergence between the Tfh and the Th1 lineages.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Chen Y,Yu Ddoi
10.1016/j.it.2015.11.001subject
Has Abstractpub_date
2015-12-01 00:00:00pages
758-760issue
12eissn
1471-4906issn
1471-4981pii
S1471-4906(15)00270-7journal_volume
36pub_type
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abstract::Tetramethylpentadecane (TMPD, or commonly known as pristane)-induced lupus is a murine model of systemic lupus erythematosus (SLE). Renal disease and autoantibody production strictly depend on signaling through the interferon (IFN)-I receptor. The major source of IFN-I is immature monocytes bearing high levels of the ...
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2005.08.013
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abstract::CD8(+) cytotoxic T lymphocyte (CTL) responses are crucial in establishing the control of persistent virus infections. Population studies of HIV-1-infected individuals suggest that CD8(+) CTL responses targeting epitopes that take the greatest toll on virus replication are instrumental in immune control. A major questi...
journal_title:Trends in immunology
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journal_title:Trends in immunology
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abstract::Astrocytes are neural parenchymal cells that ubiquitously tile the central nervous system (CNS). In addition to playing essential roles in healthy tissue, astrocytes exhibit an evolutionarily ancient response to all CNS insults, referred to as astrocyte reactivity. Long regarded as passive and homogeneous, astrocyte r...
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journal_title:Trends in immunology
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journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/s1471-4906(01)02168-8
更新日期:2002-03-01 00:00:00
abstract::Although therapy-mediated suppression of HIV-1 is effective and results in a degree of immune reconstitution, the complications resulting from life-long treatment emphasize the need for alternatives. This review discusses the use of structured interruptions in antiviral therapy to induce drug-free periods of immune-me...
journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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doi:10.1016/j.it.2011.01.004
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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doi:10.1016/j.it.2006.09.006
更新日期:2006-11-01 00:00:00
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journal_title:Trends in immunology
pub_type: 信件
doi:10.1016/j.it.2014.11.004
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journal_title:Trends in immunology
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doi:10.1016/j.it.2016.09.008
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journal_title:Trends in immunology
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2016.10.003
更新日期:2016-12-01 00:00:00
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journal_title:Trends in immunology
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2020.06.008
更新日期:2020-08-01 00:00:00
abstract::Natural killer (NK)-cell receptors (NKRs) on CD8+ T cells can modulate antigen-specific T-cell activity but their function and rules that govern their expression remain unclear. Recent work has provided new insight into CD94-NKG2A expression on T cells. Whereas upregulation on the cell surface is induced following T-c...
journal_title:Trends in immunology
pub_type: 杂志文章
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