Abstract:
:Recent epidemiological studies have shown that, in addition to disease-specific effects, vaccines against infectious diseases have nonspecific effects on the ability of the immune system to handle other pathogens. For instance, in randomized trials tuberculosis and measles vaccines are associated with a substantial reduction in overall child mortality, which cannot be explained by prevention of the target disease. New research suggests that the nonspecific effects of vaccines are related to cross-reactivity of the adaptive immune system with unrelated pathogens, and to training of the innate immune system through epigenetic reprogramming. Hence, epidemiological findings are backed by immunological data. This generates a new understanding of the immune system and about how it can be modulated by vaccines to impact the general resistance to disease.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Benn CS,Netea MG,Selin LK,Aaby Pdoi
10.1016/j.it.2013.04.004subject
Has Abstractpub_date
2013-09-01 00:00:00pages
431-9issue
9eissn
1471-4906issn
1471-4981pii
S1471-4906(13)00058-6journal_volume
34pub_type
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