Abstract：
:The concept that blood cells arising from hematopoietic stem cells (HSC) can be subdivided into two major lineages, a myelo-erythroid and a lymphoid lineage, has long persisted. Indeed, it has become almost axiomatic that the first branch point from the HSC produces two progenitors, one for myelo-erythroid cells and the other for lymphoid cells. However, recent studies have provided a battery of findings that cannot be explained by this classical model. We will outline how this classical model arose before describing how we came to propose an alternative 'myeloid-based model', in which myeloid potential is retained in erythroid, T, and B cell branches even after these lineages have segregated from each other.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Kawamoto H,Katsura Ydoi
10.1016/j.it.2009.03.001subject
Has Abstractpub_date
2009-05-01 00:00:00pages
193-200issue
5eissn
1471-4906issn
1471-4981pii
S1471-4906(09)00065-9journal_volume
30pub_type
杂志文章,评审abstract：:Autophagy is a group of cellular pathways that deliver cytoplasmic constituents for lysosomal degradation. The peptides generated from these pathways can be presented by MHC II molecules, making autophagy an important source of antigens for CD4+ T cells. In addition, modules of the molecular machinery of autophagy wer...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2016.08.017
更新日期：2016-11-01 00:00:00
abstract：:The highly polymorphic MHC class Ia molecules have a central role in adaptive immunity. By contrast, the closely related MHC class Ib molecules, which show limited polymorphism, are best known for regulating innate immune responses. Nevertheless, a recent area of interest is the emerging role of class Ib molecules in ...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2006.07.006
更新日期：2006-09-01 00:00:00
abstract：:Glioblastoma is an aggressive and incurable primary brain tumor. While the blockade of immune checkpoints leads to reversal of T cell exhaustion in many cancers, the efficacy of this therapy in glioblastoma requires further consideration of the brain microenvironment beyond T cell activity. Neural cells are crucially ...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2016.11.005
更新日期：2017-02-01 00:00:00
abstract：:Complement is a major defense system of innate immunity and aimed to destroy microbes. One of the central complement regulators is factor H, which belongs to a protein family that includes CFHL1 and five factor H-related (CFHR) proteins. Recent evidence shows that factor H family proteins (factor H and CFHRs) are asso...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2008.04.008
更新日期：2008-08-01 00:00:00
abstract：:Although the function of the circulating immune cell compartment has been studied in detail for decades, limitations in terms of access and cell yields from peripheral tissues have restricted our understanding of tissue-based immunity, particularly in humans. Recent advances in high-throughput protein analyses, transc...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2020.08.009
更新日期：2020-10-01 00:00:00
abstract：:At two checkpoints, T cell development is controlled by T cell receptor (TCR) signaling, which determines survival and lineage commitment. At the first of these checkpoints, signaling by the pre-TCR, the gammadeltaTCR or the alphabetaTCR has a major but nonexclusive impact on whether cells will become CD4-CD8- gammade...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2007.01.004
更新日期：2007-03-01 00:00:00
abstract：:The workshop on Multiple Sclerosis and Chemokines: Prospects for Therapeutic and Prophylactic Intervention was held in Chevy Chase, MD, USA, from 9-10 July 2001. ...
journal_title：Trends in immunology
pub_type：
doi：10.1016/s1471-4906(01)02056-7
更新日期：2001-11-01 00:00:00
abstract：:Inappropriate cell recruitment is a hallmark of all autoimmune, allergic and inflammatory diseases. The prevention of inflammation by interfering with cellular recruitment through the neutralization of cytokines and adhesion molecules has proven to be successful in the clinic. Chemokines are important potential target...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2005.03.001
更新日期：2005-05-01 00:00:00
abstract：:Detailed sequence analysis of the companion alpha chains in several T-cell receptor (TCR) beta chain transgenic mice have shown that the mature alpha chain repertoires of CD4+ T cells are biased toward the parental TCR alpha chain sequences. These studies further indicate that it is self-peptide-self-MHC recognition d...
journal_title：Trends in immunology
pub_type： 新闻
doi：10.1016/s1471-4906(02)02306-2
更新日期：2002-10-01 00:00:00
abstract：:Lymphocyte development has long served as an experimental paradigm, revealing fundamental mechanisms of gene regulation and cellular differentiation in mammals. The study of E-protein-mediated transcriptional regulation in lymphocyte development provides a means to address these mechanistic issues. Both genetic and bi...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2005.03.011
更新日期：2005-06-01 00:00:00
abstract：:Human immunodeficiency virus (HIV) induces a chronic generalized activation of the immune system, which plays an important role in the pathogenesis of AIDS. This ability of the virus might either be an evolved (adaptive) trait or a coincidental side effect of jumping to a new host species. We argue that selection favo...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2008.04.005
更新日期：2008-07-01 00:00:00
abstract：:Protease-activated receptors (PARs) belong to a family of G protein-coupled receptors activated by serine proteases via proteolytic cleavage. PARs are expressed on epithelial cells, endothelial cells, and leukocytes, indicating a role in controlling barrier function against external danger. During inflammation, microo...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2007.09.001
更新日期：2007-12-01 00:00:00
abstract：:To maintain prolonged colonization of the human gastric mucosa, Helicobacter pylori must avoid both innate and adaptive immune responses. During its long coexistence with humans, it has evolved complex strategies to maintain a mild inflammation of the gastric epithelium while limiting the extent of immune effector act...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2005.01.007
更新日期：2005-04-01 00:00:00
abstract：:Astrocytes are neural parenchymal cells that ubiquitously tile the central nervous system (CNS). In addition to playing essential roles in healthy tissue, astrocytes exhibit an evolutionarily ancient response to all CNS insults, referred to as astrocyte reactivity. Long regarded as passive and homogeneous, astrocyte r...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2020.07.004
更新日期：2020-09-01 00:00:00
abstract：:Inflammation is usually considered as harmful; however, it is also necessary for tissue recovery after injury. Macrophages exert immune and nonimmune functions throughout this process. During skeletal muscle regeneration, they mount an inflammatory response while exerting trophic roles on muscle and mesenchymal stem c...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2020.04.006
更新日期：2020-06-01 00:00:00
abstract：:CD8+ T cell immunological memory of past antigen exposure can confer long-lived protection against infections or tumors. The fact that CD8+ memory T cells can have features of both naïve and effector cells has forced the field to struggle with several conceptual questions about the developmental origin of the cell and...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2019.11.004
更新日期：2020-01-01 00:00:00
abstract：:House dust mites (HDM; Dermatophagoides sp.) are one of the commonest aeroallergens worldwide and up to 85% of asthmatics are typically HDM allergic. Allergenicity is associated both with the mites themselves and with ligands derived from mite-associated bacterial and fungal products. Murine models of allergic airways...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2011.06.006
更新日期：2011-09-01 00:00:00
abstract：:Adult neurogenesis plays an important role in brain function and declines with aging. A recent report demonstrates clonal T cell expansion within neurogenic niches of the aged brain, impairing neurogenesis through IFNγ signaling (Dulken et al.,Nature, 2019). These results highlight T cells as important contributors to...
journal_title：Trends in immunology
pub_type： 评论,杂志文章
doi：10.1016/j.it.2019.07.007
更新日期：2019-09-01 00:00:00
abstract：:Cytokine signaling is dependent on the activation of intracellular molecules, including JAKs (Janus family kinases) and STATs (signal transducers and activators of transcription). Since the discovery of the SOCS (suppressor of cytokine signaling) family molecules in 1997, extensive investigation of these molecules has...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2003.10.008
更新日期：2003-12-01 00:00:00
abstract：:Macrophage polarization refers to development of a specific phenotype important for tissue homeostasis or host defense in response to environmental cues. Environmental factors that induce macrophage polarization include cytokines and microbial factors produced by pathogens or commensal microbiota. Signaling pathways u...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2012.11.001
更新日期：2013-05-01 00:00:00
abstract：:T cells are known to scale their clonal expansion and effector cytokine response according to the dose and strength of antigenic signal so as to balance their role of affecting protection with the intertwined and immunologically driven tissue damage. How T cells achieve this is now beginning to be understood. We under...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2016.06.005
更新日期：2016-08-01 00:00:00
abstract：:During an immune response, peripheral T-cell populations expand and then contract as the response subsides, thus maintaining a fairly constant number of CD4 and CD8 T cells throughout the life of the individual. The important factors that control this homeostasis are now beginning to be understood. Interleukin-7 (IL-7...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2005.01.004
更新日期：2005-03-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2016.06.002
更新日期：2016-08-01 00:00:00
abstract：:The innate immune system is the first line of defense against invading pathogens and is particularly important in warding off bacterial and viral infections presenting at the mucosal cell surface. From this primitive immune response, the more sophisticated adaptive immune system was derived. Despite nearly two decades...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(01)01925-1
更新日期：2001-06-01 00:00:00
abstract：:Three recent studies provide new insight into the mechanisms that promote the differentiation of antigen-primed T cells into the follicular helper T (Tfh) lineage, revealing a key role for the transcription factor TCF-1 in the regulation of the Bcl6-Blimp-1 axis that mediates the divergence between the Tfh and the Th1...
journal_title：Trends in immunology
pub_type： 杂志文章
doi：10.1016/j.it.2015.11.001
更新日期：2015-12-01 00:00:00
abstract：:Platelets are central players in thrombosis and hemostasis but are increasingly recognized as key components of the immune system. They shape ensuing immune responses by recruiting leukocytes, and support the development of adaptive immunity. Recent data shed new light on the complex role of platelets in immunity. Her...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2019.08.004
更新日期：2019-10-01 00:00:00
abstract：:Unlike T cells that recognize digested peptides, B cells recognize their cognate antigen in its native form. The B cell receptor used in recognition can also be secreted to bind to antigens and initiate multiple effector functions such as phagocytosis, complement activation, or neutralization of receptors. While B cel...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2016.10.003
更新日期：2016-12-01 00:00:00
abstract：:Tetramethylpentadecane (TMPD, or commonly known as pristane)-induced lupus is a murine model of systemic lupus erythematosus (SLE). Renal disease and autoantibody production strictly depend on signaling through the interferon (IFN)-I receptor. The major source of IFN-I is immature monocytes bearing high levels of the ...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2009.06.003
更新日期：2009-09-01 00:00:00
abstract：:Peptides bound or linked to heat-shock proteins (HSPs) of microbial or mammalian origin have been shown to elicit potent antigen-specific immunity. Some members of the HSP family, such as hsp60, hsp70, hsp90 and gp96, are able also to stimulate cells of the innate immune system directly and thus, act as 'danger'-signa...
journal_title：Trends in immunology
pub_type： 杂志文章
doi：10.1016/s1471-4906(01)02168-8
更新日期：2002-03-01 00:00:00
abstract：:Recent studies have indicated that complement proteins might exert novel functions that are distinct from their well-established inflammatory role, by modulating cellular responses and cell-cell interactions that are crucial to early development and cell differentiation. Accumulating evidence suggests that complement ...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(02)02287-1
更新日期：2002-10-01 00:00:00
