Abstract:
:Glioblastoma is an aggressive and incurable primary brain tumor. While the blockade of immune checkpoints leads to reversal of T cell exhaustion in many cancers, the efficacy of this therapy in glioblastoma requires further consideration of the brain microenvironment beyond T cell activity. Neural cells are crucially dependent on glucose for survival, and tumor cells rabidly consume glucose; the glucose-deprived microenvironment further elevates immune checkpoint molecules to benefit tumor growth and exacerbate T cell exhaustion. We review here how immune checkpoints drive exhaustion in T cells while favoring tumor metabolism, and discuss how glucose competition in the unique CNS milieu is an important consideration to improve the outcomes of immune checkpoint blockade in glioblastoma.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Mirzaei R,Sarkar S,Yong VWdoi
10.1016/j.it.2016.11.005subject
Has Abstractpub_date
2017-02-01 00:00:00pages
104-115issue
2eissn
1471-4906issn
1471-4981pii
S1471-4906(16)30195-8journal_volume
38pub_type
杂志文章,评审abstract::In clinical practice, a successful patient-physician partnership can improve the outcome of treatment, especially in cases of chronic disease or cancer. To establish this partnership, physicians must explain treatment options and potential outcomes, but how to best do this when treatment is based on scientific princip...
journal_title:Trends in immunology
pub_type: 历史文章,杂志文章
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abstract::Mammalian group 2 innate lymphoid cells (ILC2s) are responsible for the early production of type 2 cytokines at mucosal barriers upon exposure to allergen. Inflammatory tissue environmental cues can influence ILC2 activity, and this cellular population can be further categorized into subtypes with additional or altern...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
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abstract::Activation-Induced cytidine Deaminase (AID) initiates affinity maturation and isotype switching by deaminating deoxycytidines within immunoglobulin genes, leading to somatic hypermutation (SHM) and class switch recombination (CSR). AID thus potentiates the humoral response to clear pathogens. Marking the 20th annivers...
journal_title:Trends in immunology
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abstract::CD45, the leucocyte common antigen, is a haemopoietic cell-specific tyrosine phosphatase. Many isoforms are generated by alternative splicing, but their function remains obscure. The extracellular domain of CD45 is highly polymorphic in all vertebrates. Importantly, human polymorphic variants that alter CD45 isoform e...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2006.01.001
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(02)02287-1
更新日期:2002-10-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
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journal_title:Trends in immunology
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2005.01.004
更新日期:2005-03-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(03)00166-2
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2008.05.002
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2007.03.001
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2020.09.003
更新日期:2020-11-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2016.01.002
更新日期:2016-03-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(01)02090-7
更新日期:2002-01-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2005.03.011
更新日期:2005-06-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2005.08.001
更新日期:2005-10-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/s1471-4906(02)00014-5
更新日期:2003-01-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2008.03.003
更新日期:2008-06-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2015.11.001
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2007.08.008
更新日期:2007-11-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2004.08.001
更新日期:2004-10-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2015.02.009
更新日期:2015-04-01 00:00:00
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journal_title:Trends in immunology
pub_type: 评论,杂志文章
doi:10.1016/j.it.2018.02.002
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2004.08.012
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journal_title:Trends in immunology
pub_type: 信件
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更新日期:2015-01-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
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更新日期:2001-07-01 00:00:00
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journal_title:Trends in immunology
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2012.11.001
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2008.04.008
更新日期:2008-08-01 00:00:00
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journal_title:Trends in immunology
pub_type: 新闻
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