Abstract:
:The workshop on Multiple Sclerosis and Chemokines: Prospects for Therapeutic and Prophylactic Intervention was held in Chevy Chase, MD, USA, from 9-10 July 2001.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Kivisäkk P,Trebst C,Eckstein DJ,Kerza-Kwiatecki AP,Ransohoff RMdoi
10.1016/s1471-4906(01)02056-7keywords:
subject
Has Abstractpub_date
2001-11-01 00:00:00pages
591-3issue
11eissn
1471-4906issn
1471-4981pii
S1471-4906(01)02056-7journal_volume
22pub_type
abstract::Despite readily detectable virus-specific CD8(+) T cells in most HIV-infected patients, immune surveillance is eventually lost, leading to progression to AIDS. Recently developed insights into human T-cell differentiation have been used to study the phenotype of virus-specific T cells in HIV-infected individuals. Base...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(02)02326-8
更新日期:2002-12-01 00:00:00
abstract::Complement is a major defense system of innate immunity and aimed to destroy microbes. One of the central complement regulators is factor H, which belongs to a protein family that includes CFHL1 and five factor H-related (CFHR) proteins. Recent evidence shows that factor H family proteins (factor H and CFHRs) are asso...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2008.04.008
更新日期:2008-08-01 00:00:00
abstract::Astrocytes are neural parenchymal cells that ubiquitously tile the central nervous system (CNS). In addition to playing essential roles in healthy tissue, astrocytes exhibit an evolutionarily ancient response to all CNS insults, referred to as astrocyte reactivity. Long regarded as passive and homogeneous, astrocyte r...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2020.07.004
更新日期:2020-09-01 00:00:00
abstract::CD95 (Apo-1/Fas) is crucial for the negative selection of B cells within the germinal center (GC). Impairment of CD95-mediated apoptosis results in defective affinity maturation and the persistence of autoreactive B-cell clones. CD95 was defined recently as a tumor-suppressor gene and is silenced in many tumor entitie...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(01)02115-9
更新日期:2002-02-01 00:00:00
abstract::Neurodegenerative diseases are a group of chronic, progressive disorders characterized by the gradual loss of neurons in discrete areas of the central nervous system (CNS). The mechanism(s) underlying their progressive nature remains unknown but a timely and well-controlled inflammatory reaction is essential for the i...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2008.05.002
更新日期:2008-08-01 00:00:00
abstract::Macrophages mount complex responses to pathogens. Although several key signaling pathways have been identified, it remains unclear how they work together to provide specificity. In a recent paper, Gottschalk et al. report that differential dose-response behaviors of the NFκB and MAPK pathways allow dose-specific gene ...
journal_title:Trends in immunology
pub_type: 评论,杂志文章
doi:10.1016/j.it.2016.07.003
更新日期:2016-09-01 00:00:00
abstract::In vitro-generated mesenchymal stem cells (MSCs) initially attracted interest for their ability to undergo differentiation toward cells of different lineages. More recently, a major breakthrough was the discovery that MSCs exert a profound inhibitory effect on T cell proliferation in vitro and in vivo. Subsequently, M...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2007.03.001
更新日期:2007-05-01 00:00:00
abstract::Senescent cells, albeit not proliferating, are metabolically and transcriptionally active, thereby capable of affecting their microenvironment, notably via the production of inflammatory mediators. These mediators maintain and propagate the senescence process to neighboring cells, and then recruit immune cells for cle...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2015.02.009
更新日期:2015-04-01 00:00:00
abstract::Human immunodeficiency virus (HIV) induces a chronic generalized activation of the immune system, which plays an important role in the pathogenesis of AIDS. This ability of the virus might either be an evolved (adaptive) trait or a coincidental side effect of jumping to a new host species. We argue that selection favo...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2008.04.005
更新日期:2008-07-01 00:00:00
abstract::Inflammatory bowel diseases (IBDs) are chronic debilitating conditions, which impair the patient's quality of life significantly. Among them, Crohn's disease and ulcerative colitis are idiopathic disorders for which an infective etiology has long been sought. Here, we present an opinion in support of the hypothesis th...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(01)02000-2
更新日期:2001-09-01 00:00:00
abstract::Antigen cross-presentation describes the process through which dendritic cells (DCs) acquire exogenous antigens for presentation on MHC class I molecules. The ability to cross-present has been thought of as a feature of specialized DC subsets. Emerging data, however, suggest that the cross-presenting ability of each D...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2013.02.007
更新日期:2013-08-01 00:00:00
abstract::Cytokine signaling is dependent on the activation of intracellular molecules, including JAKs (Janus family kinases) and STATs (signal transducers and activators of transcription). Since the discovery of the SOCS (suppressor of cytokine signaling) family molecules in 1997, extensive investigation of these molecules has...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2003.10.008
更新日期:2003-12-01 00:00:00
abstract::Manipulating the immune system in order to induce clinically relevant responses against cancer is a longstanding goal. Interventions to enhance tumor-specific immunity through vaccination, sustaining effector T cell activation, or increasing the numbers of tumor-specific T cells using ex vivo expansion, have all resul...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2012.08.004
更新日期:2013-02-01 00:00:00
abstract::With the identification of T helper (Th)17 cells, a specific subset of CD4 T cells expressing interleukin (IL)-17 and IL-22, research on the function of these cytokines initially largely focused on traditional adaptive immune responses. However, IL-17 and IL-22 enhance basic innate barrier defenses at mucosal surfaces...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2012.01.003
更新日期:2012-03-01 00:00:00
abstract::γδ T lymphocytes are involved in the stress response to injured epithelia and in tissue homeostasis by limiting the dissemination of malignant or infected cells and by regulating the nature of the subsequent adaptive immune response. γδ T cells have potent MHC-unrestricted cytotoxicity, a high potential for cytokine r...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2012.01.006
更新日期:2012-05-01 00:00:00
abstract::Langerhans cells (LCs) are classically viewed as unique antigen-presenting cells (APCs) that originate from embryonic precursors and maintain themselves independently in the epidermis. However, recent studies have demonstrated that murine LCs in mucosal epithelia arise and are continuously replenished from circulating...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2018.08.007
更新日期:2018-10-01 00:00:00
abstract::Recent studies have uncovered sterile alpha motif and HD domain 1 (SAMHD1) as the restriction factor that blocks HIV-1 replication in myeloid cells. In contrast to previously identified HIV-1 restriction factors, SAMHD1 does not meet a countermeasure developed by HIV-1. However, HIV-2 and certain simian immunodeficien...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2011.11.002
更新日期:2012-01-01 00:00:00
abstract::Protection against pulmonary tuberculosis (TB) by vaccination is often ascribed to the presence of TB-reactive T cells in the lung before infection. Challenging this view, new studies analyzing vaccine-induced T cells in various tissue compartments after parenteral immunization suggest a poor correlation between the p...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2010.05.002
更新日期:2010-07-01 00:00:00
abstract::Nucleotide-binding oligomerization domain protein (NOD)1 and NOD2 participate in signaling pathways that detect pathogen-induced processes, such as the presence of peptidoglycan fragments in the host cell cytosol, as danger signals. Recent work suggests that peptidoglycan fragments activate NOD1 indirectly, through ac...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2013.10.009
更新日期:2014-03-01 00:00:00
abstract::Much attention has focused on the role of co-stimulation in dictating tolerance versus immunity to internalized antigens, with the assumption that the presentation of antigen-derived peptides by MHC molecules occurs constitutively. Here, I highlight our new appreciation for the regulated presentation of phagocytosed a...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2006.11.001
更新日期:2007-01-01 00:00:00
abstract::Detailed sequence analysis of the companion alpha chains in several T-cell receptor (TCR) beta chain transgenic mice have shown that the mature alpha chain repertoires of CD4+ T cells are biased toward the parental TCR alpha chain sequences. These studies further indicate that it is self-peptide-self-MHC recognition d...
journal_title:Trends in immunology
pub_type: 新闻
doi:10.1016/s1471-4906(02)02306-2
更新日期:2002-10-01 00:00:00
abstract::Dendritic cells (DCs) have been classified into distinct subsets based on phenotype and ontogeny. In the past few years, high throughput single-cell approaches have revealed further heterogeneity of human DCs, in particular at the transcriptomic level. Herein examined, are recent studies describing new human DC popula...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2020.10.002
更新日期:2020-12-01 00:00:00
abstract::Complement is not only part of the innate immune system, but has also been implicated in adaptive immunity. The role of complement and its regulatory proteins in modulating T cell activity has been the focus of several recent studies. These, which have included work on the membrane co-factor protein (MCP or CD46), dec...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2005.12.008
更新日期:2006-02-01 00:00:00
abstract::The co-existence of viruses and organisms for millions of years has influenced the evolution of both. Various viral strategies to enter a host and take over the control of cells to produce virus progeny have developed. Several antiviral (immune) responses have also been developed. The apoptotic death program is a cons...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(03)00026-7
更新日期:2003-03-01 00:00:00
abstract::Psoriasis is a complex inflammatory process resulting from activation of the well-defined interleukin (IL)-23/T17 cytokine axis. We review the role of key cytokines IL-17 and IL-23 in psoriasis, as well as tumor necrosis factor (TNF)α, focusing on therapeutic cytokine interventions and what they reveal about psoriatic...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2012.11.005
更新日期:2013-04-01 00:00:00
abstract::Lymph nodes are strategically located throughout the body to allow lymphocytes to efficiently encounter their cognate antigen and become activated. The structure of the lymph nodes is such that B and T lymphocytes each have their own microdomain. This structure is provided by lymph node stromal cells, which also provi...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2011.10.006
更新日期:2012-06-01 00:00:00
abstract::Lung capillaries, best known for vital gas exchange, also contribute to neutrophil margination, a phenomenon resulting in large numbers of pulmonary vascular neutrophils. Importantly, the functional relevance of neutrophil margination is unknown. Recent advances in microscopy have altered our understanding of why neut...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2018.09.002
更新日期:2018-11-01 00:00:00
abstract::Non-Hodgkin lymphoma (NHL) is a diverse class of hematological cancers, many of which arise from germinal center (GC)-experienced B cells. Thus GCs, the sites of antibody affinity maturation triggered during immune responses, also provide an environment that facilitates B cell oncogenic transformation. miRNAs provide ...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2020.08.006
更新日期:2020-10-01 00:00:00
abstract::Oral tolerance is a well-characterized phenomenon in animals and is highly effective when induced as a treatment for experimental autoimmune disease. However, its use as a therapeutic modality for the treatment of autoimmune disease in humans has been disappointing. Much of the rationale for its use in humans is based...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(01)01892-0
更新日期:2001-05-01 00:00:00
abstract::Helminth parasites survive through a combination of parasite longevity, repeated re-infection and selective immune suppression to prevent protective Th2 responses. To counteract helminth-induced immunosuppression, and to induce long-term immunological memory, understanding of the multiple regulatory pathways within th...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2012.01.001
更新日期:2012-04-01 00:00:00