Abstract：
:Unlike T cells that recognize digested peptides, B cells recognize their cognate antigen in its native form. The B cell receptor used in recognition can also be secreted to bind to antigens and initiate multiple effector functions such as phagocytosis, complement activation, or neutralization of receptors. While B cells can interact with soluble antigens, it is now clear that the presentation of membrane-bound antigen plays a crucial role in B cell activation, and in particular during affinity-maturation, the process during which high-affinity B cells are selected. In this review we discuss how native antigen is presented to B cells and its impact at several stages of B cell responses.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Heesters BA,van der Poel CE,Das A,Carroll MCdoi
10.1016/j.it.2016.10.003subject
Has Abstractpub_date
2016-12-01 00:00:00pages
844-854issue
12eissn
1471-4906issn
1471-4981pii
S1471-4906(16)30151-Xjournal_volume
37pub_type
杂志文章,评审abstract：:Manipulating the immune system in order to induce clinically relevant responses against cancer is a longstanding goal. Interventions to enhance tumor-specific immunity through vaccination, sustaining effector T cell activation, or increasing the numbers of tumor-specific T cells using ex vivo expansion, have all resul...
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abstract：:Homodimeric antibodies devoid of light chains have evolved multiple times through convergent evolution, yet their specific immunological functions remain poorly understood. We survey the molecular and structural features of these antibodies, their immunological functions in host defense, and reflect on the long-standi...
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pub_type： 评论,杂志文章
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
pub_type： 评论,杂志文章
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2020-12-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章
doi：10.1016/j.it.2006.09.006
更新日期：2006-11-01 00:00:00
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journal_title：Trends in immunology
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doi：10.1016/j.it.2006.03.004
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2006.07.006
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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更新日期：2007-12-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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