Abstract：
:The immune system serves to protect organisms from infectious pathogens. During infection, lymphocytes and cells of the innate immune system, expressing receptors that recognize foreign antigens, proliferate and differentiate to develop effector functions that help to kill the pathogens. Effector functions, such as cellular or antibody mediated cytotoxicity, and inflammatory cytokines can be harmful to the host. To limit damage to healthy tissue, mechanisms have evolved to shut down immune responses, including cell inactivation and cell death. Here we discuss recent studies demonstrating that the death of antigen-activated T lymphocytes during termination of an immune response is initiated by the BH3-only Bcl-2 family member Bim and also requires its multi-BH domain pro-apoptotic relatives Bax and Bak.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Strasser A,Pellegrini Mdoi
10.1016/j.it.2004.08.012keywords:
subject
Has Abstractpub_date
2004-11-01 00:00:00pages
610-5issue
11eissn
1471-4906issn
1471-4981pii
S1471-4906(04)00264-9journal_volume
25pub_type
杂志文章,评审abstract：:The regulated secretion of cellular proteins is central to the correct function of many cell types, including immune cells. Lymphocyte control of the storage, transport and exocytosis of immunomodulatory molecules is a highly specialised task triggered by T cell receptor engagement. The regulated secretory pathway in ...
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2018-04-01 00:00:00
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更新日期：2006-03-01 00:00:00
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journal_title：Trends in immunology
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2003-12-01 00:00:00
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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更新日期：2017-12-01 00:00:00
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journal_title：Trends in immunology
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2005-11-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(03)00118-2
更新日期：2003-06-01 00:00:00
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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更新日期：2012-09-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2004-02-01 00:00:00
abstract：:Within the 'success story' of vertebrate evolution, the acquisition and refinement of the adaptive immune system is far from the least impressive example of co-evolution. Members of the tumour necrosis factor superfamily (TNFSF) and TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immun...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
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