Abstract:
:CD45, the leucocyte common antigen, is a haemopoietic cell-specific tyrosine phosphatase. Many isoforms are generated by alternative splicing, but their function remains obscure. The extracellular domain of CD45 is highly polymorphic in all vertebrates. Importantly, human polymorphic variants that alter CD45 isoform expression are associated with autoimmune and infectious diseases, establishing CD45 as an important immunomodulator with a significant influence on disease burden. Here, we discuss the new opportunities provided by the human variants for investigating and understanding how CD45 regulates antigen receptor signalling, cytokine responses and apoptosis.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Tchilian EZ,Beverley PCdoi
10.1016/j.it.2006.01.001keywords:
subject
Has Abstractpub_date
2006-03-01 00:00:00pages
146-53issue
3eissn
1471-4906issn
1471-4981pii
S1471-4906(06)00002-0journal_volume
27pub_type
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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