The Immunoregulatory Roles of Antibody Glycosylation.

Abstract:

:Beyond their role in neutralization, antibodies mediate functions such as phagocytosis, cytotoxicity, and maintenance of immune homeostasis. Two modifications to the constant domain control antibody activity: theirreversible genomic selection of isotype/subclass and alterations in glycosylation. Because glycosylation alters the affinity of antibodies for Fc receptors, evidence suggests that glycosylation is a central mechanism for the immune system to tune a broad range of biological activities. While monoclonal therapeutics have exploited glycosylation to improve function, its in vivo control and whether it may be selectively harnessed to target pathogens and/or tumors isunknown. Here, we review the process of antibody glycosylation, how it changes with disease, how it impacts antibody functionality, and the potential for deliberately controlling this biological activity.

journal_name

Trends Immunol

journal_title

Trends in immunology

authors

Jennewein MF,Alter G

doi

10.1016/j.it.2017.02.004

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

358-372

issue

5

eissn

1471-4906

issn

1471-4981

pii

S1471-4906(17)30027-3

journal_volume

38

pub_type

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