Abstract:
:Modern immunological assays are very sensitive for detection of antigen-specific T cells. These assays are used to detect increased levels of T cells after peptide-based immunotherapy for cancer in an attempt to describe surrogate endpoints correlated with anti-tumor activity. Recent reports demonstrate that determinant spreading develops in a high frequency of subjects with tumor regression responses after this type of immunotherapy and could be valuable for trial monitoring and the design of more effective vaccines.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Ribas A,Timmerman JM,Butterfield LH,Economou JSdoi
10.1016/s1471-4906(02)00029-7keywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
58-61issue
2eissn
1471-4906issn
1471-4981pii
S1471490602000297journal_volume
24pub_type
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2016.11.008
更新日期:2017-03-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
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更新日期:2001-05-01 00:00:00
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journal_title:Trends in immunology
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doi:10.1016/j.it.2019.06.005
更新日期:2019-08-01 00:00:00
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/s1471-4906(02)00014-5
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pub_type: 评论,杂志文章
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abstract::Protection against pulmonary tuberculosis (TB) by vaccination is often ascribed to the presence of TB-reactive T cells in the lung before infection. Challenging this view, new studies analyzing vaccine-induced T cells in various tissue compartments after parenteral immunization suggest a poor correlation between the p...
journal_title:Trends in immunology
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abstract::CD45, the leucocyte common antigen, is a haemopoietic cell-specific tyrosine phosphatase. Many isoforms are generated by alternative splicing, but their function remains obscure. The extracellular domain of CD45 is highly polymorphic in all vertebrates. Importantly, human polymorphic variants that alter CD45 isoform e...
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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