Abstract:
:Interleukin-1β (IL-1β) and IL-18 contribute to host defense against infection by augmenting antimicrobial properties of phagocytes and initiating Th1 and Th17 adaptive immune responses. Protein complexes called inflammasomes activate intracellular caspase-1 autocatalytically, which cleaves the inactive precursors of IL-1β and IL-18 into bioactive cytokines. In this review, we discuss the controversies regarding inflammasome activation and the role of the inflammasome during infection. We highlight alternative mechanisms for processing IL-1β and IL-18 during infection, which involve extracellular cleavage of the inactive cytokines by neutrophil-derived serine proteases or proteases released from cytotoxic T cells.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
van de Veerdonk FL,Netea MG,Dinarello CA,Joosten LAdoi
10.1016/j.it.2011.01.003subject
Has Abstractpub_date
2011-03-01 00:00:00pages
110-6issue
3eissn
1471-4906issn
1471-4981pii
S1471-4906(11)00004-4journal_volume
32pub_type
杂志文章,评审abstract::Autophagy is an evolutionarily conserved homeostatic process by which cells deliver cytoplasmic material for degradation into lysosomes. Autophagy may have evolved as a nutrient-providing homeostatic pathway induced upon starvation, but with the acquisition of cargo receptors, autophagy has become an important cellula...
journal_title:Trends in immunology
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doi:10.1016/j.it.2012.06.003
更新日期:2012-10-01 00:00:00
abstract::Recent progress in cancer immunotherapy highlights the power of the immune system to control tumors, although a small patient subset responds to current immunotherapies. Additional approaches to mobilize antitumor immunity are required to overcome primary and acquired resistance to immunotherapy such as immune checkpo...
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abstract::The concept that blood cells arising from hematopoietic stem cells (HSC) can be subdivided into two major lineages, a myelo-erythroid and a lymphoid lineage, has long persisted. Indeed, it has become almost axiomatic that the first branch point from the HSC produces two progenitors, one for myelo-erythroid cells and t...
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abstract::The entry of exogenous antigen into the MHC class I-restricted cross-presentation pathway can contribute to CD8(+) T cell tolerance and immunity, in particular to peripheral self-antigens or selected viruses and bacteria showing restricted tissue tropism. Dendritic cells are the key cross-presenting cells and, as such...
journal_title:Trends in immunology
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journal_title:Trends in immunology
pub_type: 新闻
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更新日期:2002-10-01 00:00:00
abstract::The introduction of combined antiretroviral therapies (HAART) has reversed the fatal course of human immunodeficiency virus (HIV) infection. HAART controls virus production and, in most cases, allows the quantitative and functional immune defects caused by HIV to be reversed. Here, we review T cell homeostatic mechani...
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journal_title:Trends in immunology
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
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journal_title:Trends in immunology
pub_type: 评论,杂志文章
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journal_title:Trends in immunology
pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2011.02.006
更新日期:2011-05-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2004.07.006
更新日期:2004-09-01 00:00:00
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journal_title:Trends in immunology
pub_type: 评审
doi:10.1016/j.it.2014.10.005
更新日期:2014-12-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/s1471-4906(03)00060-7
更新日期:2003-04-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(01)02000-2
更新日期:2001-09-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2016.01.002
更新日期:2016-03-01 00:00:00
abstract::Monoclonal antibodies (mAbs) are in widespread use for the treatment of cancer. Their success as cancer therapeutics relies substantially on their ability to engage the immune system. Specifically, Fc-receptor-expressing immune cells mediate the killing of tumor cells by mAbs. Stimulation of these immune effector cell...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2011.07.003
更新日期:2011-11-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2004.08.001
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journal_title:Trends in immunology
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2006.07.006
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journal_title:Trends in immunology
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doi:10.1016/j.it.2009.06.003
更新日期:2009-09-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章
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abstract::Recent studies have reported paradoxical roles of inflammation in tumor immunity triggered by PD-1 checkpoint antibody (Ab) blockade. Here, we elaborate on this controversy and propose a new perspective that might help understand this paradox. Since inflammatory cytokines and PD-1 blockade are known to target differen...
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2007.07.004
更新日期:2007-09-01 00:00:00
abstract::T cell metabolism has a central role in supporting and shaping immune responses and may have a key role in antitumor immunity. T cell metabolism is normally held under tight regulation in an immune response of glycolysis to promote effector T cell expansion and function. However, tumors may deplete nutrients, generate...
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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更新日期:2005-10-01 00:00:00
abstract::Inducing sustained, robust CD8(+) T cell responses is necessary for therapeutic intervention in chronic infectious diseases and cancer. Unfortunately, most adjuvant formulations fail to induce substantial cellular immunity in humans. Attenuated acute infectious agents induce strong CD8(+) T cell immunity, and are thou...
journal_title:Trends in immunology
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doi:10.1016/j.it.2016.01.001
更新日期:2016-03-01 00:00:00