Abstract：
:Tetramethylpentadecane (TMPD, or commonly known as pristane)-induced lupus is a murine model of systemic lupus erythematosus (SLE). Renal disease and autoantibody production strictly depend on signaling through the interferon (IFN)-I receptor. The major source of IFN-I is immature monocytes bearing high levels of the surface marker Ly6C. Interferon production is mediated exclusively by signaling through TLR7 and the adapter protein MyD88. It is likely that endogenous TLR7 ligands such as components of small nuclear ribonucleoprotein complexes are involved in triggering disease. Lupus autoantibodies are produced in ectopic lymphoid tissue developing in response to TMPD. This model is well suited for examining links between dysregulated IFN-I production and the pathogenesis of human SLE, which like TMPD-lupus, is associated with high levels of IFN-I.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Reeves WH,Lee PY,Weinstein JS,Satoh M,Lu Ldoi
10.1016/j.it.2009.06.003subject
Has Abstractpub_date
2009-09-01 00:00:00pages
455-64issue
9eissn
1471-4906issn
1471-4981pii
S1471-4906(09)00135-5journal_volume
30pub_type
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