Abstract：
:Plasma cells operate as factories where large quantities of Ig heavy and light chains are made and assembled into functional antibodies. The finished products are shipped out with impressive efficiency. A major component of the machinery necessary for high-rate antibody secretion is an elaborate network of endoplasmic reticulum (ER), the site of antibody biosynthesis. Recent discoveries have provided insights into how this expansive secretory machinery is built, equipped and maintained. The unfolded protein response (UPR) pathway, a stress-induced signaling cascade emanating from the ER, regulates the expression and activity of X-box binding protein 1, a transcription factor required for plasma-cell development. The UPR pathway therefore senses conditions in the ER--the very compartment where antibodies are formed--and directs events required for humoral immunity.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Gass JN,Gunn KE,Sriburi R,Brewer JWdoi
10.1016/j.it.2003.11.004keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
17-24issue
1eissn
1471-4906issn
1471-4981pii
S1471490603003594journal_volume
25pub_type
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