Abstract:
:Migration of hematopoietic stem cells (HSCs) is essential during embryonic development and throughout adult life. During embryogenesis, trafficking of HSCs is responsible for the sequential colonization of different hematopoietic organs by blood-producing cells. In adulthood, circulation of HSCs maintains homeostasis of the hematopoietic system and participates in innate immune responses. HSC trafficking is also crucial in clinical settings such as bone marrow (BM) and stem cell transplantation. This review provides an overview of the molecular and cellular signals that control and fine-tune trafficking of HSCs and hematopoietic progenitor cells in embryogenesis and during postnatal life. We also discuss the potential clinical utility of therapeutic approaches to modulate HSC trafficking in patients.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Mazo IB,Massberg S,von Andrian UHdoi
10.1016/j.it.2011.06.011subject
Has Abstractpub_date
2011-10-01 00:00:00pages
493-503issue
10eissn
1471-4906issn
1471-4981pii
S1471-4906(11)00117-7journal_volume
32pub_type
杂志文章,评审abstract::Immune 'checkpoint' inhibitors can increase the activity of tumor-resident cytotoxic lymphocytes and have revolutionized cancer treatment. Current therapies block inhibitory pathways in tumor-infiltrating CD8+ T cells and recent studies have shown similar programs in other effector populations such as natural killer (...
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
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journal_title:Trends in immunology
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doi:10.1016/j.it.2016.01.002
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doi:10.1016/j.it.2020.10.002
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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doi:10.1016/j.it.2010.05.002
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journal_title:Trends in immunology
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更新日期:2006-03-01 00:00:00
abstract::Epstein-Barr Virus (EBV) is one of the most successful human viruses, infecting more than 90% of the adult population worldwide and persisting for the lifetime of the host. Individuals with a history of symptomatic primary EBV infection, called infectious mononucleosis, carry a moderately higher risk of developing mul...
journal_title:Trends in immunology
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doi:10.1016/j.it.2009.03.007
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journal_title:Trends in immunology
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abstract::Human immunodeficiency virus (HIV) induces a chronic generalized activation of the immune system, which plays an important role in the pathogenesis of AIDS. This ability of the virus might either be an evolved (adaptive) trait or a coincidental side effect of jumping to a new host species. We argue that selection favo...
journal_title:Trends in immunology
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journal_title:Trends in immunology
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