Abstract:
:A prominent population of innate CD8+ T cells develops in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3. These cells have the phenotype and function of memory CD8+ T cells, without previous exposure to antigen. Surprisingly, the cytokine IL-4 plays a key role in their development. As this developmental mechanism was discovered, it came to light that innate CD8+ T cells exist also in normal mice and in humans. In this review, we discuss how these cells develop, compare and contrast them to other CD8 memory cells, and discuss their potential physiological relevance.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Lee YJ,Jameson SC,Hogquist KAdoi
10.1016/j.it.2010.12.004subject
Has Abstractpub_date
2011-02-01 00:00:00pages
50-6issue
2eissn
1471-4906issn
1471-4981pii
S1471-4906(10)00172-9journal_volume
32pub_type
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journal_title:Trends in immunology
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2003-06-01 00:00:00
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更新日期:2002-02-01 00:00:00
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更新日期:2003-07-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2008.07.004
更新日期:2008-10-01 00:00:00
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journal_title:Trends in immunology
pub_type: 评论,杂志文章
doi:10.1016/j.it.2019.07.007
更新日期:2019-09-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/j.it.2016.01.001
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doi:10.1016/j.it.2017.05.004
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journal_title:Trends in immunology
pub_type: 评论,杂志文章
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2012.08.004
更新日期:2013-02-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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abstract::Helminth parasites survive through a combination of parasite longevity, repeated re-infection and selective immune suppression to prevent protective Th2 responses. To counteract helminth-induced immunosuppression, and to induce long-term immunological memory, understanding of the multiple regulatory pathways within th...
journal_title:Trends in immunology
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abstract::Interleukin-1β (IL-1β) and IL-18 contribute to host defense against infection by augmenting antimicrobial properties of phagocytes and initiating Th1 and Th17 adaptive immune responses. Protein complexes called inflammasomes activate intracellular caspase-1 autocatalytically, which cleaves the inactive precursors of I...
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doi:10.1016/s1471-4906(01)01862-2
更新日期:2001-04-01 00:00:00
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abstract::Natural killer (NK)-cell receptors (NKRs) on CD8+ T cells can modulate antigen-specific T-cell activity but their function and rules that govern their expression remain unclear. Recent work has provided new insight into CD94-NKG2A expression on T cells. Whereas upregulation on the cell surface is induced following T-c...
journal_title:Trends in immunology
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更新日期:2003-04-01 00:00:00
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