Abstract：
:Natural killer (NK)-cell receptors (NKRs) on CD8+ T cells can modulate antigen-specific T-cell activity but their function and rules that govern their expression remain unclear. Recent work has provided new insight into CD94-NKG2A expression on T cells. Whereas upregulation on the cell surface is induced following T-cell receptor (TCR) engagement, commitment to CD94-NKG2A expression is a clonal attribute. NKRs can therefore shape cytotoxic T-lymphocyte (CTL) responses and should be considered in designing vaccine therapies.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Braud VM,Aldemir H,Breart B,Ferlin WGdoi
10.1016/s1471-4906(03)00064-4keywords:
subject
Has Abstractpub_date
2003-04-01 00:00:00pages
162-4issue
4eissn
1471-4906issn
1471-4981pii
S1471490603000644journal_volume
24pub_type
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journal_title：Trends in immunology
pub_type： 杂志文章
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更新日期：2001-11-01 00:00:00
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journal_title：Trends in immunology
pub_type： 评论,杂志文章
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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abstract：:When and how adaptive immunity emerged is one of the fundamental questions in immunology. Accumulated evidence suggests that the key components of adaptive immunity, rearranging receptor genes and the MHC, are unique to jawed vertebrates. Recent studies in protochordates, in particular, the draft genome sequence of th...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2003.11.005
更新日期：2004-02-01 00:00:00
abstract：:One major determinant of systemic immunity during homeostasis and in certain complex multifactorial diseases (e.g. cancer and autoimmune conditions), is the gut microbiota. These commensals can shape systemic immune responses via translocation of metabolites, microbial cell wall components, and viable microbes. In the...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2021-02-01 00:00:00
abstract：:Whether MHC restriction by the T cell receptor (TCR) is a product of evolutionary pressures leading to germline-encoded 'rules of engagement' remains avidly debated. Structural results derived from analysis of TCR-peptide-MHC complexes appear to support a model of physical specificity between TCR germline V regions an...
journal_title：Trends in immunology
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更新日期：2012-09-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2005-06-01 00:00:00
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journal_title：Trends in immunology
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2013-03-01 00:00:00
abstract：:The highly polymorphic MHC class Ia molecules have a central role in adaptive immunity. By contrast, the closely related MHC class Ib molecules, which show limited polymorphism, are best known for regulating innate immune responses. Nevertheless, a recent area of interest is the emerging role of class Ib molecules in ...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2006.07.006
更新日期：2006-09-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2017-10-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章
doi：10.1016/j.it.2006.03.003
更新日期：2006-05-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2020.09.003
更新日期：2020-11-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2011.10.001
更新日期：2012-01-01 00:00:00
abstract：:Common variable immunodeficiency (CVID) is an immune disorder that not only causes increased susceptibility to infection, but also to inflammatory complications such as autoimmunity, lymphoid proliferation, malignancy, and granulomatous disease. Recent findings implicate the microbiome as a driver of this systemic imm...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2016.11.008
更新日期：2017-03-01 00:00:00
abstract：:Lung capillaries, best known for vital gas exchange, also contribute to neutrophil margination, a phenomenon resulting in large numbers of pulmonary vascular neutrophils. Importantly, the functional relevance of neutrophil margination is unknown. Recent advances in microscopy have altered our understanding of why neut...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2018.09.002
更新日期：2018-11-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2005.09.002
更新日期：2005-11-01 00:00:00
abstract：:Human immunodeficiency virus (HIV) induces a chronic generalized activation of the immune system, which plays an important role in the pathogenesis of AIDS. This ability of the virus might either be an evolved (adaptive) trait or a coincidental side effect of jumping to a new host species. We argue that selection favo...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2008.04.005
更新日期：2008-07-01 00:00:00
abstract：:Toll-like receptors (TLRs) are sensors of foreign microbial products, which initiate host defense responses in all multicellular organisms examined to date. They are the target for most adjuvants, are essential for the establishment of memory in T and B cells and provoke inflammation. They program dendritic cells in t...
journal_title：Trends in immunology
pub_type： 传,历史文章,杂志文章,评审
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更新日期：2004-12-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2006.01.001
更新日期：2006-03-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2003-02-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章
doi：10.1016/s1471-4906(02)00014-5
更新日期：2003-01-01 00:00:00
abstract：:Chronic viral infections and cancer often lead to the emergence of dysfunctional or 'exhausted' CD8+ T cells, and the restoration of their functions is currently the focus of therapeutic interventions. In this review, we detail recent advances in the annotation of the gene modules and the epigenetic landscape associat...
journal_title：Trends in immunology
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更新日期：2017-08-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(00)01822-6
更新日期：2001-03-01 00:00:00
abstract：:Platelets are central players in thrombosis and hemostasis but are increasingly recognized as key components of the immune system. They shape ensuing immune responses by recruiting leukocytes, and support the development of adaptive immunity. Recent data shed new light on the complex role of platelets in immunity. Her...
journal_title：Trends in immunology
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更新日期：2019-10-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2015.02.009
更新日期：2015-04-01 00:00:00
abstract：:The activation and differentiation of CD8 T cells is a necessary first step that endows these cells with the phenotypic and functional properties required for the control of intracellular pathogens. The induction of the CD8 T cell responses typically results in the development of a massive overall population of effect...
journal_title：Trends in immunology
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更新日期：2011-04-01 00:00:00
abstract：:Many patients suffer from neuropathic pain as a result of injury to the peripheral nervous system (e.g. post-herpetic neuralgia or diabetic neuropathy) or to the central nervous system (e.g. spinal cord injury or stroke). The most distinctive symptom of neuropathic pain is allodynia, whereby normally non-painful stimu...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2005.08.001
更新日期：2005-10-01 00:00:00
