Abstract：
:The activation and differentiation of CD8 T cells is a necessary first step that endows these cells with the phenotypic and functional properties required for the control of intracellular pathogens. The induction of the CD8 T cell responses typically results in the development of a massive overall population of effector cells, comprising both highly functional but short-lived terminally differentiated cells, as well as a smaller subset of precursors that are predisposed to survive and transition into the memory T cell pool. In this review, we discuss how inflammatory cytokines and IL-2 bias the initial response towards short-lived effector generation, and also highlight the potential counterbalancing role of IL-21.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Cox MA,Harrington LE,Zajac AJdoi
10.1016/j.it.2011.01.004subject
Has Abstractpub_date
2011-04-01 00:00:00pages
180-6issue
4eissn
1471-4906issn
1471-4981pii
S1471-4906(11)00005-6journal_volume
32pub_type
杂志文章,评审abstract：:Lung capillaries, best known for vital gas exchange, also contribute to neutrophil margination, a phenomenon resulting in large numbers of pulmonary vascular neutrophils. Importantly, the functional relevance of neutrophil margination is unknown. Recent advances in microscopy have altered our understanding of why neut...
journal_title：Trends in immunology
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abstract：:Epstein-Barr Virus (EBV) is one of the most successful human viruses, infecting more than 90% of the adult population worldwide and persisting for the lifetime of the host. Individuals with a history of symptomatic primary EBV infection, called infectious mononucleosis, carry a moderately higher risk of developing mul...
journal_title：Trends in immunology
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doi：10.1016/j.it.2009.03.007
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pub_type： 评论,杂志文章
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abstract：:Systemic sclerosis (SSc, also known as scleroderma) has the highest case-specific mortality among the rheumatic diseases; however, advances in understanding of pathogenesis and an appreciation of the clinical heterogeneity of this disease, together with therapeutic advances in other areas, have raised the possibility ...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2005.09.002
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abstract：:Inflammation is usually considered as harmful; however, it is also necessary for tissue recovery after injury. Macrophages exert immune and nonimmune functions throughout this process. During skeletal muscle regeneration, they mount an inflammatory response while exerting trophic roles on muscle and mesenchymal stem c...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2020.04.006
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abstract：:Glioblastoma is an aggressive and incurable primary brain tumor. While the blockade of immune checkpoints leads to reversal of T cell exhaustion in many cancers, the efficacy of this therapy in glioblastoma requires further consideration of the brain microenvironment beyond T cell activity. Neural cells are crucially ...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2015.08.005
更新日期：2015-10-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2013.03.006
更新日期：2013-09-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2018.08.007
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2017-04-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2006.01.001
更新日期：2006-03-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2020-12-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章
doi：10.1016/j.it.2006.09.006
更新日期：2006-11-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2006.07.006
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2013.10.009
更新日期：2014-03-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2003.10.008
更新日期：2003-12-01 00:00:00
abstract：:Two recent crystal structures of membrane attack complex/perforin (MACPF) domains found in the complement and perforin families unexpectedly reveal that some proteins of the immune system share a common core fold with their bacterial targets. Although a relationship between MACPF proteins and the previously characteri...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2007.11.003
更新日期：2008-02-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
pub_type： 评论,杂志文章
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2020-11-01 00:00:00
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journal_title：Trends in immunology
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更新日期：2017-08-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2003-08-01 00:00:00
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journal_title：Trends in immunology
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doi：10.1016/j.it.2005.03.011
更新日期：2005-06-01 00:00:00
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journal_title：Trends in immunology
pub_type： 评论,杂志文章
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更新日期：2020-05-01 00:00:00
abstract：:Much attention has focused on the role of co-stimulation in dictating tolerance versus immunity to internalized antigens, with the assumption that the presentation of antigen-derived peptides by MHC molecules occurs constitutively. Here, I highlight our new appreciation for the regulated presentation of phagocytosed a...
journal_title：Trends in immunology
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更新日期：2007-01-01 00:00:00
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journal_title：Trends in immunology
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abstract：:The ocular surface is a unique mucosal immune compartment in which anatomical, physiological, and immunological features act in concert to foster a particularly tolerant microenvironment. These mechanisms are vital to the functional competence of the eye, a fact underscored by the devastating toll of excessive inflamm...
journal_title：Trends in immunology
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doi：10.1016/j.it.2017.11.007
更新日期：2018-04-01 00:00:00
abstract：:CD95 (Apo-1/Fas) is crucial for the negative selection of B cells within the germinal center (GC). Impairment of CD95-mediated apoptosis results in defective affinity maturation and the persistence of autoreactive B-cell clones. CD95 was defined recently as a tumor-suppressor gene and is silenced in many tumor entitie...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
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