Abstract:
:Much attention has focused on the role of co-stimulation in dictating tolerance versus immunity to internalized antigens, with the assumption that the presentation of antigen-derived peptides by MHC molecules occurs constitutively. Here, I highlight our new appreciation for the regulated presentation of phagocytosed antigens by MHC class II molecules as a direct result of controlling phagosome maturation by Toll-like receptors. I discuss how the mode of antigen delivery into dendritic cells coupled with the right type of signal transduction pathway can impact greatly not only the co-stimulatory context in which the antigen is presented to naive T cells (signal 2) but MHC-II presentation of the antigen and formation of the T-cell receptor ligand (signal 1) itself.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Blander JMdoi
10.1016/j.it.2006.11.001subject
Has Abstractpub_date
2007-01-01 00:00:00pages
19-25issue
1eissn
1471-4906issn
1471-4981pii
S1471-4906(06)00323-1journal_volume
28pub_type
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