Abstract:
:Although the function of the circulating immune cell compartment has been studied in detail for decades, limitations in terms of access and cell yields from peripheral tissues have restricted our understanding of tissue-based immunity, particularly in humans. Recent advances in high-throughput protein analyses, transcriptional profiling, and epigenetics have partially overcome these obstacles. Innate lymphoid cells (ILCs) are predominantly tissue-resident, and accumulating data indicate that they have significant tissue-specific functions. We summarize current knowledge of ILC phenotypes in various tissues in mice and humans, aiming to clarify ILC immunity in distinct anatomical locations.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Meininger I,Carrasco A,Rao A,Soini T,Kokkinou E,Mjösberg Jdoi
10.1016/j.it.2020.08.009subject
Has Abstractpub_date
2020-10-01 00:00:00pages
902-917issue
10eissn
1471-4906issn
1471-4981pii
S1471-4906(20)30186-1journal_volume
41pub_type
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