Abstract:
:Over the years, the role of the eosinophil in asthma and allergic processes has been disputed. Recent human experiments using a humanised monoclonal antibody to interleukin-5 (IL-5), and animal studies involving specific IL-5 gene deletion, indicates that eosinophils might control downstream repair and remodelling processes. Eosinophils are a rich source of fibrogenic factors, particularly transforming growth factor-beta (TGF-beta), the latent form of which is activated by epithelial-cell expression of the intergin alpha(v)beta(6). The emerging role for the eosinophil in airway remodelling might be important in future anti-asthma strategies. However, more effective eosinophil-depleting agents than anti-IL-5 are required before the definitive role of this cell type in asthma airway pathophysiology can be established.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Kay AB,Phipps S,Robinson DSdoi
10.1016/j.it.2004.07.006keywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
477-82issue
9eissn
1471-4906issn
1471-4981pii
S1471-4906(04)00214-5journal_volume
25pub_type
杂志文章,评审abstract::Non-deletional tolerance resulting in the generation of regulatory T cells within the thymus is a key mechanism for the establishment of immunological self-tolerance. How the high-affinity self-reactive regulatory T cells escape negative selection and what type of antigen-presenting cells positively select them within...
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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abstract::Immunoreceptors are believed to initiate their signaling by association with membrane rafts rich in src-family kinases and other signaling molecules. Although a recent paper casts doubt over this concept, by exposing drawbacks of a commonly used procedure to disturb rafts by cholesterol extraction, several other recen...
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journal_title:Trends in immunology
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更新日期:2002-12-01 00:00:00
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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doi:10.1016/j.it.2003.10.008
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2007.11.003
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pub_type: 杂志文章,评审
doi:10.1016/j.it.2008.05.002
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journal_title:Trends in immunology
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journal_title:Trends in immunology
pub_type: 新闻
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abstract::The signaling lymphocytic activation molecule (SLAM) and SLAM-associated protein (SAP) families have key roles in normal immunity. They have also been implicated in diseases such as immunodeficiencies and auto-immunity. However, recent findings raise issues requiring examination in future investigations of these molec...
journal_title:Trends in immunology
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doi:10.1016/j.it.2006.03.003
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journal_title:Trends in immunology
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doi:10.1016/j.it.2009.06.003
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journal_title:Trends in immunology
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abstract::Unlike T cells that recognize digested peptides, B cells recognize their cognate antigen in its native form. The B cell receptor used in recognition can also be secreted to bind to antigens and initiate multiple effector functions such as phagocytosis, complement activation, or neutralization of receptors. While B cel...
journal_title:Trends in immunology
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doi:10.1016/j.it.2016.10.003
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