Origins of the RAG Transposome and the MHC.

Abstract:

:How innate immunity gave rise to adaptive immunity in vertebrates remains unknown. We propose an evolutionary scenario beginning with pathogen-associated molecular pattern(s) (PAMPs) being presented by molecule(s) on one cell to specific receptor(s) on other cells, much like MHC molecules and T cell receptors (TCRs). In this model, mutations in MHC-like molecule(s) that bound new PAMP(s) would not be recognized by original TCR-like molecule(s), and new MHC-like gene(s) would be lost by neutral drift. Integrating recombination activating gene (RAG) transposon(s) in a TCR-like gene would result in greater recognition diversity, with new MHC-like variants recognized and selected, along with a new RAG/TCR-like system. MHC genes would be selected to present many peptides, through multigene families, allelic polymorphism, and peptide-binding promiscuity.

journal_name

Trends Immunol

journal_title

Trends in immunology

authors

Tsakou-Ngouafo L,Paganini J,Kaufman J,Pontarotti P

doi

10.1016/j.it.2020.05.002

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

561-571

issue

7

eissn

1471-4906

issn

1471-4981

pii

S1471-4906(20)30097-1

journal_volume

41

pub_type

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