Abstract：
:The mechanisms accounting for the protective role of endogenous interferon gamma (IFN-gamma) in certain murine autoimmune disease models, versus a disease-promoting role in others, have remained elusive. The protective effect of IFN-gamma might be unique to models that rely on the use of complete Freund's adjuvant (CFA) and whose pathogenesis is predominantly driven by delayed-type hypersensitivity. In these models, IFN-gamma counteracts disease development by inhibiting CFA-induced proliferation of a pathogenically important Mac-1(+) cell population(s). This calls into question our usual conceptualization of the balance between innate and specific immunity in these models, as well as their clinical relevance, particularly when the role of IFN-gamma or related cytokines is considered.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Matthys P,Vermeire K,Billiau Adoi
10.1016/s1471-4906(01)01937-8keywords:
subject
Has Abstractpub_date
2001-07-01 00:00:00pages
367-71issue
7eissn
1471-4906issn
1471-4981pii
S1471-4906(01)01937-8journal_volume
22pub_type
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