Abstract：
:CD95 (Apo-1/Fas) is crucial for the negative selection of B cells within the germinal center (GC). Impairment of CD95-mediated apoptosis results in defective affinity maturation and the persistence of autoreactive B-cell clones. CD95 was defined recently as a tumor-suppressor gene and is silenced in many tumor entities. In contrast to other malignancies, in GC-derived B-cell lymphomas, inactivation of the CD95 gene is often a result of deleterious mutations. Such mutations occur also at a low frequency in normal GC, but not naive, B cells. We propose that CD95 mutations in B-cell lymphomas originate from the GC reaction and are introduced most probably as targeting errors of the somatic hypermutation machinery, which bears--besides its physiological role--an inherent risk of malignant transformation and the persistence of autoreactive B-cell specificities.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Müschen M,Rajewsky K,Krönke M,Küppers Rdoi
10.1016/s1471-4906(01)02115-9keywords:
subject
Has Abstractpub_date
2002-02-01 00:00:00pages
75-80issue
2eissn
1471-4906issn
1471-4981pii
S1471490601021159journal_volume
23pub_type
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journal_title：Trends in immunology
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更新日期：2002-01-01 00:00:00
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2002-10-01 00:00:00
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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