Abstract:
:Peptides bound or linked to heat-shock proteins (HSPs) of microbial or mammalian origin have been shown to elicit potent antigen-specific immunity. Some members of the HSP family, such as hsp60, hsp70, hsp90 and gp96, are able also to stimulate cells of the innate immune system directly and thus, act as 'danger'-signaling molecules. This effect is independent of HSP-associated peptides and, in many respects, resembles the effect of lipopolysaccharide (LPS). Here, we discuss the similarities between the responses to HSPs and LPS and also, emphasize that care must be taken when working with preparations of HSPs in experimental settings and interpreting experimental data.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Wallin RP,Lundqvist A,Moré SH,von Bonin A,Kiessling R,Ljunggren HGdoi
10.1016/s1471-4906(01)02168-8keywords:
subject
Has Abstractpub_date
2002-03-01 00:00:00pages
130-5issue
3eissn
1471-4906issn
1471-4981pii
S1471490601021688journal_volume
23pub_type
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abstract::Unlike T cells that recognize digested peptides, B cells recognize their cognate antigen in its native form. The B cell receptor used in recognition can also be secreted to bind to antigens and initiate multiple effector functions such as phagocytosis, complement activation, or neutralization of receptors. While B cel...
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journal_title:Trends in immunology
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abstract::Recent studies have uncovered sterile alpha motif and HD domain 1 (SAMHD1) as the restriction factor that blocks HIV-1 replication in myeloid cells. In contrast to previously identified HIV-1 restriction factors, SAMHD1 does not meet a countermeasure developed by HIV-1. However, HIV-2 and certain simian immunodeficien...
journal_title:Trends in immunology
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abstract::The immune system confines neoplasia at various stages of tumor development. Whereas the role of cellular immunity has been investigated widely and utilized in the clinic, the importance of humoral immunity in this process has begun to emerge only in recent years. Circulating antinuclear autoantibodies (ANAs) typicall...
journal_title:Trends in immunology
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abstract::Protection against pulmonary tuberculosis (TB) by vaccination is often ascribed to the presence of TB-reactive T cells in the lung before infection. Challenging this view, new studies analyzing vaccine-induced T cells in various tissue compartments after parenteral immunization suggest a poor correlation between the p...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2010.05.002
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
pub_type: 评论,杂志文章
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journal_title:Trends in immunology
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doi:10.1016/s1471-4906(02)02326-8
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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doi:10.1016/j.it.2010.12.002
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journal_title:Trends in immunology
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doi:10.1016/j.it.2007.11.003
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2014.02.001
更新日期:2014-03-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2003.11.005
更新日期:2004-02-01 00:00:00
abstract::Recent advances allow aging-associated changes in B-cell function to be approached at a mechanistic level. Reduced expression of genes crucial to lineage commitment and differentiation yield diminished B-cell production. Moreover, intrinsic differences in the repertoire generated by B-cell precursors in aged individua...
journal_title:Trends in immunology
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doi:10.1016/j.it.2009.04.005
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journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2011.07.003
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journal_title:Trends in immunology
pub_type: 杂志文章
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journal_title:Trends in immunology
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abstract::Caspase recruitment domain-containing protein (Card)9 is a nonredundant adapter protein that functions in the innate immune system in the assembly of multifunctional signaling complexes. Together with B cell lymphoma (Bcl)10 and the paracaspase, mucosa-associated lymphoid tissue lymphoma translocation protein (Malt)1,...
journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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更新日期:2016-06-01 00:00:00
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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doi:10.1016/j.it.2018.12.003
更新日期:2019-02-01 00:00:00
abstract::T follicular helper (TFH) cells are characteristically defined by their CXCR5 positivity and homing to B cell follicles in secondary lymphoid organs (SLO). An expanded subpopulation of functionally comparable and phenotypically similar PD-1hiCXCR5-CD4+ T cells were recently identified in breast cancer (BC) and rheumat...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2017.10.003
更新日期:2017-12-01 00:00:00
abstract::The understanding of tumor-host interactions remains elusive despite significant progress in the identification of tumor antigens (TAs) recognized by autologous T cells. In particular, most human tumors do not regress and continue to grow in spite of spontaneous or immunization-induced immune responses demonstrated in...
journal_title:Trends in immunology
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doi:10.1016/s1471-4906(03)00116-9
更新日期:2003-06-01 00:00:00