Abstract:
:Protection against pulmonary tuberculosis (TB) by vaccination is often ascribed to the presence of TB-reactive T cells in the lung before infection. Challenging this view, new studies analyzing vaccine-induced T cells in various tissue compartments after parenteral immunization suggest a poor correlation between the presence of anti-TB T cells in the lung interstitium and spleen before Mycobacterium tuberculosis exposure and protection. In contrast, respiratory mucosal immunization leads to distribution of T cells not only in the lung interstitium and spleen, but also in the airway lumen, and the presence of these cells correlates well with protection. Furthermore, airway luminal recruitment of parenteral vaccine-induced T cells in peripheral tissues prior to M. tuberculosis challenge restores protection. We propose that understanding the biology of airway luminal T cells holds important implications for developing effective TB vaccination strategies.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Jeyanathan M,Heriazon A,Xing Zdoi
10.1016/j.it.2010.05.002subject
Has Abstractpub_date
2010-07-01 00:00:00pages
247-52issue
7eissn
1471-4906issn
1471-4981pii
S1471-4906(10)00063-3journal_volume
31pub_type
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doi:10.1016/j.it.2008.05.002
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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doi:10.1016/j.it.2003.08.003
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