Innate immune mechanisms for recognition and uptake of Candida species.

abstract：:The understanding of tumor-host interactions remains elusive despite significant progress in the identification of tumor antigens (TAs) recognized by autologous T cells. In particular, most human tumors do not regress and continue to grow in spite of spontaneous or immunization-induced immune responses demonstrated in...

journal_title：Trends in immunology

authors： Marincola FM,Wang E,Herlyn M,Seliger B,Ferrone S

更新日期：2003-06-01 00:00:00

abstract：:Recent progress in cancer immunotherapy highlights the power of the immune system to control tumors, although a small patient subset responds to current immunotherapies. Additional approaches to mobilize antitumor immunity are required to overcome primary and acquired resistance to immunotherapy such as immune checkpo...

journal_title：Trends in immunology

authors： Kim HJ,Cantor H,Cosmopoulos K

更新日期：2020-10-01 00:00:00

abstract：:Adult neurogenesis plays an important role in brain function and declines with aging. A recent report demonstrates clonal T cell expansion within neurogenic niches of the aged brain, impairing neurogenesis through IFNγ signaling (Dulken et al.,Nature, 2019). These results highlight T cells as important contributors to...

journal_title：Trends in immunology

authors： Rustenhoven J,Herz J,Kipnis J

更新日期：2019-09-01 00:00:00

abstract：:γδ T lymphocytes are involved in the stress response to injured epithelia and in tissue homeostasis by limiting the dissemination of malignant or infected cells and by regulating the nature of the subsequent adaptive immune response. γδ T cells have potent MHC-unrestricted cytotoxicity, a high potential for cytokine r...

journal_title：Trends in immunology

authors： Hannani D,Ma Y,Yamazaki T,Déchanet-Merville J,Kroemer G,Zitvogel L

更新日期：2012-05-01 00:00:00

abstract：:The circadian system ensures the generation and maintenance of self-sustained ~24-h rhythms in physiology that are linked to internal and environmental changes. In mammals, daily variations in light intensity and other cues are integrated by a hypothalamic master clock that conveys circadian information to peripheral ...

journal_title：Trends in immunology

authors： Arjona A,Silver AC,Walker WE,Fikrig E

更新日期：2012-12-01 00:00:00

abstract：:T cells, as orchestrators of the adaptive immune response, serve important physiological and potentially therapeutic roles, for example in cancer immunotherapy. T cells are readily isolated from patients; however, the yield of antigen-specific T cells is limited, thus making their clinical use challenging. Therefore, ...

journal_title：Trends in immunology

authors： Brauer PM,Singh J,Xhiku S,Zúñiga-Pflücker JC

更新日期：2016-12-01 00:00:00

abstract：:The MHC class II transcriptional activator (CIITA) is the major regulator of expression of MHC class II genes. Thus, CIITA plays a fundamental role in the regulation of the immune response. Here, we discuss our findings on the dual role of CIITA during infections, as the target (prey) for certain pathogens but the hos...

journal_title：Trends in immunology

authors： Accolla RS,De Lerma Barbaro A,Mazza S,Casoli C,De Maria A,Tosi G

更新日期：2001-10-01 00:00:00

abstract：:Common variable immunodeficiency (CVID) is an immune disorder that not only causes increased susceptibility to infection, but also to inflammatory complications such as autoimmunity, lymphoid proliferation, malignancy, and granulomatous disease. Recent findings implicate the microbiome as a driver of this systemic imm...

journal_title：Trends in immunology

authors： Berbers RM,Nierkens S,van Laar JM,Bogaert D,Leavis HL

更新日期：2017-03-01 00:00:00

abstract：:The immune system serves to protect organisms from infectious pathogens. During infection, lymphocytes and cells of the innate immune system, expressing receptors that recognize foreign antigens, proliferate and differentiate to develop effector functions that help to kill the pathogens. Effector functions, such as ce...

journal_title：Trends in immunology

authors： Strasser A,Pellegrini M

更新日期：2004-11-01 00:00:00

abstract：:Lymph nodes are strategically located throughout the body to allow lymphocytes to efficiently encounter their cognate antigen and become activated. The structure of the lymph nodes is such that B and T lymphocytes each have their own microdomain. This structure is provided by lymph node stromal cells, which also provi...

journal_title：Trends in immunology

authors： Koning JJ,Mebius RE

更新日期：2012-06-01 00:00:00

abstract：:Amyloid formation contributes to the development of progressive metabolic and neurodegenerative diseases, while also serving functional roles in host defense. Emerging evidence suggests that as amyloidogenic peptides populate distinct aggregation states, they interact with different combinations of pattern recognition...

journal_title：Trends in immunology

authors： Westwell-Roper C,Verchere CB

更新日期：2019-08-01 00:00:00

abstract：:Cell migration is crucial for intrathymic T-cell differentiation. Chemokines and extracellular matrix proteins per se induce thymocyte migration, and recent data suggest a combinatorial role for these molecules in this event. For example, thymocyte migration induced by fibronectin plus CXCL12/SDF1-alpha (stromal cell-...

journal_title：Trends in immunology

authors： Savino W,Mendes-da-Cruz DA,Silva JS,Dardenne M,Cotta-de-Almeida V

更新日期：2002-06-01 00:00:00

abstract：:The crucial clinical problem in leprosy is the occurrence of acute inflammatory episodes that lead to nerve damage, even after the infecting organisms have been killed by antibiotics. We suggest that the instability of these inflammatory sites is attributable to a disturbance of the role that nerves play in the regula...

journal_title：Trends in immunology

authors： Rook GA,Lightman SL,Heijnen CJ

更新日期：2002-01-01 00:00:00

abstract：:The innate immune system is the first line of defense against invading pathogens and is particularly important in warding off bacterial and viral infections presenting at the mucosal cell surface. From this primitive immune response, the more sophisticated adaptive immune system was derived. Despite nearly two decades...

journal_title：Trends in immunology

authors： Levy JA

更新日期：2001-06-01 00:00:00

abstract：:Macrophage polarization refers to development of a specific phenotype important for tissue homeostasis or host defense in response to environmental cues. Environmental factors that induce macrophage polarization include cytokines and microbial factors produced by pathogens or commensal microbiota. Signaling pathways u...

journal_title：Trends in immunology

authors： Ivashkiv LB

更新日期：2013-05-01 00:00:00

abstract：:There is a growing body of evidence suggesting that bacterial signaling molecules are involved in cross-kingdom communication with eukaryotic cells. Bacterial signaling molecules can enter eukaryotic cells and appear to modulate immune responses to bacterial pathogens. Recently, an enticing study demonstrated that mam...

journal_title：Trends in immunology

authors： Sperandio V

更新日期：2004-10-01 00:00:00

abstract：:Modern immunological assays are very sensitive for detection of antigen-specific T cells. These assays are used to detect increased levels of T cells after peptide-based immunotherapy for cancer in an attempt to describe surrogate endpoints correlated with anti-tumor activity. Recent reports demonstrate that determina...

journal_title：Trends in immunology

authors： Ribas A,Timmerman JM,Butterfield LH,Economou JS

更新日期：2003-02-01 00:00:00

abstract：:In autoimmune disease, a network of diverse cytokines is produced in association with disease susceptibility to constitute the 'cytokine milieu' that drives chronic inflammation. It remains elusive how cytokines interact in such a complex network to sustain inflammation in autoimmune disease. This has presented huge c...

journal_title：Trends in immunology

authors： Liu X,Fang L,Guo TB,Mei H,Zhang JZ

更新日期：2013-03-01 00:00:00

abstract：:Psoriasis is a complex inflammatory process resulting from activation of the well-defined interleukin (IL)-23/T17 cytokine axis. We review the role of key cytokines IL-17 and IL-23 in psoriasis, as well as tumor necrosis factor (TNF)α, focusing on therapeutic cytokine interventions and what they reveal about psoriatic...

journal_title：Trends in immunology

authors： Lowes MA,Russell CB,Martin DA,Towne JE,Krueger JG

更新日期：2013-04-01 00:00:00

abstract：:Over the years, the role of the eosinophil in asthma and allergic processes has been disputed. Recent human experiments using a humanised monoclonal antibody to interleukin-5 (IL-5), and animal studies involving specific IL-5 gene deletion, indicates that eosinophils might control downstream repair and remodelling pro...

journal_title：Trends in immunology

authors： Kay AB,Phipps S,Robinson DS

更新日期：2004-09-01 00:00:00

abstract：:The recent Zika virus (ZIKV) epidemic has created an urgent need for a safe and effective vaccine. There is still a dearth of knowledge about ZIKV immunity, but years of investigation into the immunobiology of other flaviviruses has helped to accelerate the development of a ZIKV vaccine. Although the humoral immune re...

journal_title：Trends in immunology

authors： Lima NS,Rolland M,Modjarrad K,Trautmann L

更新日期：2017-08-01 00:00:00

abstract：:Detailed sequence analysis of the companion alpha chains in several T-cell receptor (TCR) beta chain transgenic mice have shown that the mature alpha chain repertoires of CD4+ T cells are biased toward the parental TCR alpha chain sequences. These studies further indicate that it is self-peptide-self-MHC recognition d...

journal_title：Trends in immunology

authors： He X,Viret C,Janeway CA Jr

更新日期：2002-10-01 00:00:00

abstract：:Dendritic cells (DCs) have been classified into distinct subsets based on phenotype and ontogeny. In the past few years, high throughput single-cell approaches have revealed further heterogeneity of human DCs, in particular at the transcriptomic level. Herein examined, are recent studies describing new human DC popula...

journal_title：Trends in immunology

authors： Villar J,Segura E

更新日期：2020-12-01 00:00:00

abstract：:Mast cells are currently recognized as effector cells in many settings beyond just allergic reactions, including innate immunity, autoimmunity, chronic inflammatory disorders and atherosclerosis. Signaling pathways of the mast cell response have been widely explored in the past but these are still linked with single a...

journal_title：Trends in immunology

authors： Bachelet I,Levi-Schaffer F

更新日期：2007-08-01 00:00:00

abstract：:The concept that blood cells arising from hematopoietic stem cells (HSC) can be subdivided into two major lineages, a myelo-erythroid and a lymphoid lineage, has long persisted. Indeed, it has become almost axiomatic that the first branch point from the HSC produces two progenitors, one for myelo-erythroid cells and t...

journal_title：Trends in immunology

authors： Kawamoto H,Katsura Y

更新日期：2009-05-01 00:00:00

abstract：:Epstein-Barr Virus (EBV) is one of the most successful human viruses, infecting more than 90% of the adult population worldwide and persisting for the lifetime of the host. Individuals with a history of symptomatic primary EBV infection, called infectious mononucleosis, carry a moderately higher risk of developing mul...

journal_title：Trends in immunology

authors： Lünemann JD,Münz C

更新日期：2009-06-01 00:00:00

abstract：:Within the 'success story' of vertebrate evolution, the acquisition and refinement of the adaptive immune system is far from the least impressive example of co-evolution. Members of the tumour necrosis factor superfamily (TNFSF) and TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immun...

journal_title：Trends in immunology

authors： Collette Y,Gilles A,Pontarotti P,Olive D

更新日期：2003-07-01 00:00:00

abstract：:Recent advances in genome analysis have provided important insights into the genetic architecture of infectious and inflammatory diseases. The combined analysis of loci detected by genome-wide association studies (GWAS) in 22 inflammatory diseases has revealed a shared genetic core and associated biochemical pathways ...

journal_title：Trends in immunology

authors： Fodil N,Langlais D,Gros P

更新日期：2016-02-01 00:00:00

abstract：:Beyond their role in neutralization, antibodies mediate functions such as phagocytosis, cytotoxicity, and maintenance of immune homeostasis. Two modifications to the constant domain control antibody activity: theirreversible genomic selection of isotype/subclass and alterations in glycosylation. Because glycosylation ...

journal_title：Trends in immunology

authors： Jennewein MF,Alter G

更新日期：2017-05-01 00:00:00

abstract：:Two studies show that adding NOTCH ligands to Flt3L cultures increases the yield of cDC1s from mouse and human progenitors. Moreover, these NOTCH-DCs more closely resemble in vivo DCs transcriptionally and functionally. This will be extremely valuable for studying DCs in vitro and for further developing autologous DC-...

journal_title：Trends in immunology

authors： Guilliams M,Scott CL

更新日期：2018-10-01 00:00:00