Abstract:
:Dendritic cells (DCs) have been classified into distinct subsets based on phenotype and ontogeny. In the past few years, high throughput single-cell approaches have revealed further heterogeneity of human DCs, in particular at the transcriptomic level. Herein examined, are recent studies describing new human DC populations based on single-cell RNA-seq analysis, and a unified view of these emerging DC populations is presented. Also assessed are the features that define bona fide DC lineages, as opposed to cell states of the same lineage. Finally, where these newly described DC populations fit in the ontogeny-based classification of human DCs is examined.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Villar J,Segura Edoi
10.1016/j.it.2020.10.002subject
Has Abstractpub_date
2020-12-01 00:00:00pages
1062-1071issue
12eissn
1471-4906issn
1471-4981pii
S1471-4906(20)30231-3journal_volume
41pub_type
杂志文章,评审abstract::Lung capillaries, best known for vital gas exchange, also contribute to neutrophil margination, a phenomenon resulting in large numbers of pulmonary vascular neutrophils. Importantly, the functional relevance of neutrophil margination is unknown. Recent advances in microscopy have altered our understanding of why neut...
journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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doi:10.1016/j.it.2016.06.002
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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