Abstract:
:Common variable immunodeficiency (CVID) is an immune disorder that not only causes increased susceptibility to infection, but also to inflammatory complications such as autoimmunity, lymphoid proliferation, malignancy, and granulomatous disease. Recent findings implicate the microbiome as a driver of this systemic immune dysregulation. Here, we critically review the current evidence for a role of the microbiome in the pathogenesis of CVID immune dysregulation, and describe the possible immunologic mechanisms behind causes and consequences of microbial dysbiosis in CVID. We integrate this evidence into a model describing a role for the gut microbiota in the maintenance of inflammation and immune dysregulation in CVID, and suggest research strategies to contribute to the development of new diagnostic tools and therapeutic targets.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Berbers RM,Nierkens S,van Laar JM,Bogaert D,Leavis HLdoi
10.1016/j.it.2016.11.008subject
Has Abstractpub_date
2017-03-01 00:00:00pages
206-216issue
3eissn
1471-4906issn
1471-4981pii
S1471-4906(16)30204-6journal_volume
38pub_type
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