Microbial Dysbiosis in Common Variable Immune Deficiencies: Evidence, Causes, and Consequences.

Abstract:

:Common variable immunodeficiency (CVID) is an immune disorder that not only causes increased susceptibility to infection, but also to inflammatory complications such as autoimmunity, lymphoid proliferation, malignancy, and granulomatous disease. Recent findings implicate the microbiome as a driver of this systemic immune dysregulation. Here, we critically review the current evidence for a role of the microbiome in the pathogenesis of CVID immune dysregulation, and describe the possible immunologic mechanisms behind causes and consequences of microbial dysbiosis in CVID. We integrate this evidence into a model describing a role for the gut microbiota in the maintenance of inflammation and immune dysregulation in CVID, and suggest research strategies to contribute to the development of new diagnostic tools and therapeutic targets.

journal_name

Trends Immunol

journal_title

Trends in immunology

authors

Berbers RM,Nierkens S,van Laar JM,Bogaert D,Leavis HL

doi

10.1016/j.it.2016.11.008

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

206-216

issue

3

eissn

1471-4906

issn

1471-4981

pii

S1471-4906(16)30204-6

journal_volume

38

pub_type

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