Abstract：
:Within the 'success story' of vertebrate evolution, the acquisition and refinement of the adaptive immune system is far from the least impressive example of co-evolution. Members of the tumour necrosis factor superfamily (TNFSF) and TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity. Here, we propose a detailed description of the phylogenetic relations of the TNFSF and TNFRSF members and offer evidence that the divergence of the TNFSF and TNFRSF families paralleled the emergence of the adaptive immune system, at least partly through en bloc duplication. Unexpectedly, TNFSF subfamilies form monophyletic groups with shared functions, including TNFRSF usage. Finally, the mechanisms of (co-)evolution of TNFSF and TNFRSF are discussed.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Collette Y,Gilles A,Pontarotti P,Olive Ddoi
10.1016/s1471-4906(03)00166-2keywords:
subject
Has Abstractpub_date
2003-07-01 00:00:00pages
387-94issue
7eissn
1471-4906issn
1471-4981pii
S1471490603001662journal_volume
24pub_type
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