Abstract:
:Manipulating the immune system in order to induce clinically relevant responses against cancer is a longstanding goal. Interventions to enhance tumor-specific immunity through vaccination, sustaining effector T cell activation, or increasing the numbers of tumor-specific T cells using ex vivo expansion, have all resulted in clinical successes. Here, we examine recent clinical advances and major ongoing studies in the field of cancer immunotherapy. Single agents have so far benefited a limited proportion of patients, and future studies combining different types of immunotherapies and other therapeutic modalities, such as drugs against specific signaling pathways driving cancer cell growth, are needed to pave the way for the development of effective anticancer treatments causing durable responses.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Gao J,Bernatchez C,Sharma P,Radvanyi LG,Hwu Pdoi
10.1016/j.it.2012.08.004subject
Has Abstractpub_date
2013-02-01 00:00:00pages
90-8issue
2eissn
1471-4906issn
1471-4981pii
S1471-4906(12)00142-1journal_volume
34pub_type
杂志文章,评审abstract::The circadian system ensures the generation and maintenance of self-sustained ~24-h rhythms in physiology that are linked to internal and environmental changes. In mammals, daily variations in light intensity and other cues are integrated by a hypothalamic master clock that conveys circadian information to peripheral ...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2012.08.007
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abstract::In lymphatic tissue, professional antigen-presenting cells (APCs) such as dendritic cells (DCs), mature after sensing microbe-associated molecular patterns (MAMPs) by pattern recognition receptors (PRRs), and subsequently activate T cell immunity. Non-pathogenic MAMPs, derived for example from commensal bacteria, are ...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
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abstract::Recent studies have reported paradoxical roles of inflammation in tumor immunity triggered by PD-1 checkpoint antibody (Ab) blockade. Here, we elaborate on this controversy and propose a new perspective that might help understand this paradox. Since inflammatory cytokines and PD-1 blockade are known to target differen...
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abstract::Migration of hematopoietic stem cells (HSCs) is essential during embryonic development and throughout adult life. During embryogenesis, trafficking of HSCs is responsible for the sequential colonization of different hematopoietic organs by blood-producing cells. In adulthood, circulation of HSCs maintains homeostasis ...
journal_title:Trends in immunology
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doi:10.1016/j.it.2011.06.011
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abstract::The entry of exogenous antigen into the MHC class I-restricted cross-presentation pathway can contribute to CD8(+) T cell tolerance and immunity, in particular to peripheral self-antigens or selected viruses and bacteria showing restricted tissue tropism. Dendritic cells are the key cross-presenting cells and, as such...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2006.12.008
更新日期:2007-02-01 00:00:00
abstract::T cells are known to scale their clonal expansion and effector cytokine response according to the dose and strength of antigenic signal so as to balance their role of affecting protection with the intertwined and immunologically driven tissue damage. How T cells achieve this is now beginning to be understood. We under...
journal_title:Trends in immunology
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doi:10.1016/j.it.2016.06.005
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abstract::In vitro-generated mesenchymal stem cells (MSCs) initially attracted interest for their ability to undergo differentiation toward cells of different lineages. More recently, a major breakthrough was the discovery that MSCs exert a profound inhibitory effect on T cell proliferation in vitro and in vivo. Subsequently, M...
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pub_type: 杂志文章,评审
doi:10.1016/j.it.2007.03.001
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abstract::CD8+ T cell immunological memory of past antigen exposure can confer long-lived protection against infections or tumors. The fact that CD8+ memory T cells can have features of both naïve and effector cells has forced the field to struggle with several conceptual questions about the developmental origin of the cell and...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2019.11.004
更新日期:2020-01-01 00:00:00
abstract::The full potential of T cell-based immunotherapies remains limited by a variety of T cell extrinsic and intrinsic immunosuppressive mechanisms that can become imprinted to stably reduce the antitumor ability of T cells. Here, we discuss recent insights into memory CD8+ T cell differentiation and exhaustion and the ass...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2020.06.008
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abstract::The concept that blood cells arising from hematopoietic stem cells (HSC) can be subdivided into two major lineages, a myelo-erythroid and a lymphoid lineage, has long persisted. Indeed, it has become almost axiomatic that the first branch point from the HSC produces two progenitors, one for myelo-erythroid cells and t...
journal_title:Trends in immunology
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doi:10.1016/j.it.2009.03.001
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abstract::Tetramethylpentadecane (TMPD, or commonly known as pristane)-induced lupus is a murine model of systemic lupus erythematosus (SLE). Renal disease and autoantibody production strictly depend on signaling through the interferon (IFN)-I receptor. The major source of IFN-I is immature monocytes bearing high levels of the ...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2009.06.003
更新日期:2009-09-01 00:00:00
abstract::How allergens trigger the T helper 2 (Th2) response that characterizes allergic lung inflammation is not well understood. Epithelium-derived alarmins released after an allergen encounter activate the innate immune system, including group 2 innate lymphoid cells (ILC2s) which produce the type 2 interleukins IL-5 and IL...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2015.01.005
更新日期:2015-03-01 00:00:00
abstract::The F4/80 monoclonal antibody has been used widely as a marker for mouse macrophages. The antigen (Ag) recognized by the antibody has been characterized as a member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family, although the function of the molecule has remained elusive. A recent study provides evi...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2005.07.008
更新日期:2005-10-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(01)01892-0
更新日期:2001-05-01 00:00:00
abstract::Hepatitis C virus (HCV) uses complex and unique mechanisms to prevent, evade or subvert innate and adaptive immune responses and to establish persistent infection and chronic hepatitis. Recently developed experimental systems have significantly facilitated the analysis of HCV replication, virus-host interaction and pa...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(03)00178-9
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abstract::Despite readily detectable virus-specific CD8(+) T cells in most HIV-infected patients, immune surveillance is eventually lost, leading to progression to AIDS. Recently developed insights into human T-cell differentiation have been used to study the phenotype of virus-specific T cells in HIV-infected individuals. Base...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(02)02326-8
更新日期:2002-12-01 00:00:00
abstract::Immuno-gene therapy can be advantageously performed with nonviral approaches. Genes that encode regulatory cytokines or inflammatory cytokine inhibitors can be delivered intramuscularly and expressed for weeks or months. This type of gene transfer into muscle has been shown to ameliorate several autoimmune diseases an...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(00)01822-6
更新日期:2001-03-01 00:00:00
abstract::Non-deletional tolerance resulting in the generation of regulatory T cells within the thymus is a key mechanism for the establishment of immunological self-tolerance. How the high-affinity self-reactive regulatory T cells escape negative selection and what type of antigen-presenting cells positively select them within...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2006.03.004
更新日期:2006-05-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2005.01.007
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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doi:10.1016/j.it.2003.08.003
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abstract::Antigen cross-presentation describes the process through which dendritic cells (DCs) acquire exogenous antigens for presentation on MHC class I molecules. The ability to cross-present has been thought of as a feature of specialized DC subsets. Emerging data, however, suggest that the cross-presenting ability of each D...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2013.02.007
更新日期:2013-08-01 00:00:00
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journal_title:Trends in immunology
pub_type: 新闻
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abstract::In addition to exogenous ligands derived from pathogens, natural killer (NK) and other innate cells can recognize endogenous ligands that often act as markers of stress or damage. A recent study reports that one of these receptors, human NKp44, recognizes PDGF-DD, providing a rare example of the recognition of a solub...
journal_title:Trends in immunology
pub_type: 评论,杂志文章
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更新日期:2018-05-01 00:00:00
abstract::The regulated secretion of cellular proteins is central to the correct function of many cell types, including immune cells. Lymphocyte control of the storage, transport and exocytosis of immunomodulatory molecules is a highly specialised task triggered by T cell receptor engagement. The regulated secretory pathway in ...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2007.08.008
更新日期:2007-11-01 00:00:00
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journal_title:Trends in immunology
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doi:10.1016/j.it.2005.08.006
更新日期:2005-10-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2016.11.005
更新日期:2017-02-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2005.08.013
更新日期:2005-11-01 00:00:00