Abstract：
:In lymphatic tissue, professional antigen-presenting cells (APCs) such as dendritic cells (DCs), mature after sensing microbe-associated molecular patterns (MAMPs) by pattern recognition receptors (PRRs), and subsequently activate T cell immunity. Non-pathogenic MAMPs, derived for example from commensal bacteria, are delivered to the liver from the gastrointestinal tract via the portal vein. However, in contrast to splenic DCs, PRRs-expressing liver APCs induce T cell tolerance rather than immunity. This is explained partly by the distinct effects of PRRs on the maturation of liver APCs: these cells activate T cell immunity only when PRRs stimulation is accompanied by microbial infection through mechanisms that are not employed by DCs in lymphatic tissue. Understanding the molecular basis of T cell tolerance and immunity in the liver may help develop novel immune therapy for persistent viral infection or liver cancer.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Kern M,Popov A,Kurts C,Schultze JL,Knolle PAdoi
10.1016/j.it.2010.06.001subject
Has Abstractpub_date
2010-08-01 00:00:00pages
311-7issue
8eissn
1471-4906issn
1471-4981pii
S1471-4906(10)00079-7journal_volume
31pub_type
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