Abstract：
:Non-deletional tolerance resulting in the generation of regulatory T cells within the thymus is a key mechanism for the establishment of immunological self-tolerance. How the high-affinity self-reactive regulatory T cells escape negative selection and what type of antigen-presenting cells positively select them within the thymus are unsolved questions. Previous studies suggest that thymic epithelial cells are crucial for the positive selection of regulatory T cells in thymus. A recent study from my group shows that a subset of dendritic cells (that have been "educated" by the thymic stromal lymphopoietin molecule produced by a thymic cell type known as Hassall's corpuscles) positively select regulatory T cells within the medulla of human thymus. Here, I discuss the implications and historical context of this new result and suggest that a subset of mature dendritic cells within the thymic medulla protects the medium- to high-affinity self-reactive T cells from negative deletion and induces their differentiation into regulatory T cells in the thymus.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Liu YJdoi
10.1016/j.it.2006.03.004keywords:
subject
Has Abstractpub_date
2006-05-01 00:00:00pages
215-21issue
5eissn
1471-4906issn
1471-4981pii
S1471-4906(06)00091-3journal_volume
27pub_type
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