Abstract：
:Harmless microbes colonizing the gut require the establishment of a well-equilibrated symbiosis between this microbiota and its host. However, the immune system is primed to recognize both conserved microbial patterns and foreign antigens, and therefore developed strong tolerance mechanisms to prevent potential fatal immune reactivity to symbiotic microbes. The transcription factor RAR-related orphan-like γt [ROR(γt); encoded by Rorc] plays a key role in the gut for lymphoid tissue organogenesis, development of innate lymphoid cells type 3 (ILC3s) and proinflammatory type 17 T helper (Th17) cells. Surprisingly, recent research has revealed a contribution of ROR(γt)-expressing cells in a variety of tolerance mechanisms in both the innate and adaptive immune system.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Ohnmacht Cdoi
10.1016/j.it.2016.05.002subject
Has Abstractpub_date
2016-07-01 00:00:00pages
477-486issue
7eissn
1471-4906issn
1471-4981pii
S1471-4906(16)30034-5journal_volume
37pub_type
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