Abstract:
:Immunoreceptors are believed to initiate their signaling by association with membrane rafts rich in src-family kinases and other signaling molecules. Although a recent paper casts doubt over this concept, by exposing drawbacks of a commonly used procedure to disturb rafts by cholesterol extraction, several other recent papers give further support to the concept.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Horejsí Vdoi
10.1016/s1471-4906(02)02330-xkeywords:
subject
Has Abstractpub_date
2002-12-01 00:00:00pages
562-4issue
12eissn
1471-4906issn
1471-4981pii
S147149060202330Xjournal_volume
23pub_type
新闻abstract::Mast cells are currently recognized as effector cells in many settings beyond just allergic reactions, including innate immunity, autoimmunity, chronic inflammatory disorders and atherosclerosis. Signaling pathways of the mast cell response have been widely explored in the past but these are still linked with single a...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2007.06.007
更新日期:2007-08-01 00:00:00
abstract::Evolutionarily, how RAG endonucleases in vertebrate immune systems could shed dangerous transposon-like propensities, and instead, support the organized assembly of antigen receptor variable domains, has been unclear. Recent structural work by Schatz and colleagues (Nature, 2019) identifies features of the RAG endonuc...
journal_title:Trends in immunology
pub_type: 评论,杂志文章
doi:10.1016/j.it.2019.06.007
更新日期:2019-08-01 00:00:00
abstract::The origin of the Toll-like family of receptors pre-dates the evolutionary split between the plant and animal kingdoms. These receptors are remarkably conserved across the taxonomic kingdoms and have fundamental roles in triggering immune responses. How they trigger such responses, and how these mechanisms arose in ev...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/s1471-4906(02)00014-5
更新日期:2003-01-01 00:00:00
abstract::Non-deletional tolerance resulting in the generation of regulatory T cells within the thymus is a key mechanism for the establishment of immunological self-tolerance. How the high-affinity self-reactive regulatory T cells escape negative selection and what type of antigen-presenting cells positively select them within...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2006.03.004
更新日期:2006-05-01 00:00:00
abstract::Lung capillaries, best known for vital gas exchange, also contribute to neutrophil margination, a phenomenon resulting in large numbers of pulmonary vascular neutrophils. Importantly, the functional relevance of neutrophil margination is unknown. Recent advances in microscopy have altered our understanding of why neut...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2018.09.002
更新日期:2018-11-01 00:00:00
abstract::CD8(+) cytotoxic T lymphocyte (CTL) responses are crucial in establishing the control of persistent virus infections. Population studies of HIV-1-infected individuals suggest that CD8(+) CTL responses targeting epitopes that take the greatest toll on virus replication are instrumental in immune control. A major questi...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2009.12.003
更新日期:2010-03-01 00:00:00
abstract::Human immunodeficiency virus (HIV) induces a chronic generalized activation of the immune system, which plays an important role in the pathogenesis of AIDS. This ability of the virus might either be an evolved (adaptive) trait or a coincidental side effect of jumping to a new host species. We argue that selection favo...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2008.04.005
更新日期:2008-07-01 00:00:00
abstract::T-bet was originally described as the key transcription factor defining type 1 T helper (Th) cells. However, it is now clear that it drives the orchestrated generation of effector and memory cells in multiple different lymphocyte lineages. In addition to Th1 cells, CD8 T cells, B cells and some innate lymphocyte popul...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2017.02.003
更新日期:2017-04-01 00:00:00
abstract::Many diseases have an inflammatory component, where neutrophil interactions with the vascular endothelium lead to barrier dysfunction and increased permeability. Neutrophils increase permeability through secreted products such as the chemokines CXCL1, 2, 3, and 8, through adhesion-dependent processes involving beta(2)...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2009.07.012
更新日期:2009-11-01 00:00:00
abstract::Adult neurogenesis plays an important role in brain function and declines with aging. A recent report demonstrates clonal T cell expansion within neurogenic niches of the aged brain, impairing neurogenesis through IFNγ signaling (Dulken et al.,Nature, 2019). These results highlight T cells as important contributors to...
journal_title:Trends in immunology
pub_type: 评论,杂志文章
doi:10.1016/j.it.2019.07.007
更新日期:2019-09-01 00:00:00
abstract::Lymph nodes are strategically located throughout the body to allow lymphocytes to efficiently encounter their cognate antigen and become activated. The structure of the lymph nodes is such that B and T lymphocytes each have their own microdomain. This structure is provided by lymph node stromal cells, which also provi...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2011.10.006
更新日期:2012-06-01 00:00:00
abstract::Protection against pulmonary tuberculosis (TB) by vaccination is often ascribed to the presence of TB-reactive T cells in the lung before infection. Challenging this view, new studies analyzing vaccine-induced T cells in various tissue compartments after parenteral immunization suggest a poor correlation between the p...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2010.05.002
更新日期:2010-07-01 00:00:00
abstract::CD103(+) dendritic cells (DCs) represent the major migratory DC population in the intestinal lamina propria and are believed to play an essential role in the initiation and regulation of mucosal adaptive immune responses. Small intestine (SI) CD103(+) DCs have an enhanced capacity to generate the vitamin A metabolite,...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2011.10.001
更新日期:2012-01-01 00:00:00
abstract::Modern immunological assays are very sensitive for detection of antigen-specific T cells. These assays are used to detect increased levels of T cells after peptide-based immunotherapy for cancer in an attempt to describe surrogate endpoints correlated with anti-tumor activity. Recent reports demonstrate that determina...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(02)00029-7
更新日期:2003-02-01 00:00:00
abstract::γδ T lymphocytes are involved in the stress response to injured epithelia and in tissue homeostasis by limiting the dissemination of malignant or infected cells and by regulating the nature of the subsequent adaptive immune response. γδ T cells have potent MHC-unrestricted cytotoxicity, a high potential for cytokine r...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2012.01.006
更新日期:2012-05-01 00:00:00
abstract::An exemplar outcome of an immunology-based intervention is vaccine development; the current COVID-19 pandemic is a case in point. Can we build an immunology research ecosystem in Africa that nurtures discovery and enables translation? We see African immunologists as key agents of change and discuss obstacles and oppor...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2020.10.007
更新日期:2020-12-01 00:00:00
abstract::Tetramethylpentadecane (TMPD, or commonly known as pristane)-induced lupus is a murine model of systemic lupus erythematosus (SLE). Renal disease and autoantibody production strictly depend on signaling through the interferon (IFN)-I receptor. The major source of IFN-I is immature monocytes bearing high levels of the ...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2009.06.003
更新日期:2009-09-01 00:00:00
abstract::The activation and differentiation of CD8 T cells is a necessary first step that endows these cells with the phenotypic and functional properties required for the control of intracellular pathogens. The induction of the CD8 T cell responses typically results in the development of a massive overall population of effect...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2011.01.004
更新日期:2011-04-01 00:00:00
abstract::Homodimeric antibodies devoid of light chains have evolved multiple times through convergent evolution, yet their specific immunological functions remain poorly understood. We survey the molecular and structural features of these antibodies, their immunological functions in host defense, and reflect on the long-standi...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2018.09.008
更新日期:2018-12-01 00:00:00
abstract::The immune system serves to protect organisms from infectious pathogens. During infection, lymphocytes and cells of the innate immune system, expressing receptors that recognize foreign antigens, proliferate and differentiate to develop effector functions that help to kill the pathogens. Effector functions, such as ce...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2004.08.012
更新日期:2004-11-01 00:00:00
abstract::Autophagy is a group of cellular pathways that deliver cytoplasmic constituents for lysosomal degradation. The peptides generated from these pathways can be presented by MHC II molecules, making autophagy an important source of antigens for CD4+ T cells. In addition, modules of the molecular machinery of autophagy wer...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2016.08.017
更新日期:2016-11-01 00:00:00
abstract::In many flowering plants, intraspecific barriers to self-fertilization ensure outbreeding by interrupting the path of pollen tube growth before egg-sperm interaction. These self-sterility or self-incompatibility (SI) systems are unique among recognition systems, in that they are based on the recognition and rejection ...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2005.06.005
更新日期:2005-08-01 00:00:00
abstract::Oral tolerance is a well-characterized phenomenon in animals and is highly effective when induced as a treatment for experimental autoimmune disease. However, its use as a therapeutic modality for the treatment of autoimmune disease in humans has been disappointing. Much of the rationale for its use in humans is based...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(01)01892-0
更新日期:2001-05-01 00:00:00
abstract::Monoclonal antibodies (mAbs) are in widespread use for the treatment of cancer. Their success as cancer therapeutics relies substantially on their ability to engage the immune system. Specifically, Fc-receptor-expressing immune cells mediate the killing of tumor cells by mAbs. Stimulation of these immune effector cell...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2011.07.003
更新日期:2011-11-01 00:00:00
abstract::The highly polymorphic MHC class Ia molecules have a central role in adaptive immunity. By contrast, the closely related MHC class Ib molecules, which show limited polymorphism, are best known for regulating innate immune responses. Nevertheless, a recent area of interest is the emerging role of class Ib molecules in ...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2006.07.006
更新日期:2006-09-01 00:00:00
abstract::Recent studies have uncovered sterile alpha motif and HD domain 1 (SAMHD1) as the restriction factor that blocks HIV-1 replication in myeloid cells. In contrast to previously identified HIV-1 restriction factors, SAMHD1 does not meet a countermeasure developed by HIV-1. However, HIV-2 and certain simian immunodeficien...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2011.11.002
更新日期:2012-01-01 00:00:00
abstract::In vitro-generated mesenchymal stem cells (MSCs) initially attracted interest for their ability to undergo differentiation toward cells of different lineages. More recently, a major breakthrough was the discovery that MSCs exert a profound inhibitory effect on T cell proliferation in vitro and in vivo. Subsequently, M...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2007.03.001
更新日期:2007-05-01 00:00:00
abstract::Dynamics plays an important but underappreciated role in the interaction between the T cell receptor (TCR) and peptide-bound major histocompatibility complex (pMHC). Crystallographic studies have provided key molecular insights into this interaction; however, due to inherent features of the structural approach, the im...
journal_title:Trends in immunology
pub_type: 评审
doi:10.1016/j.it.2014.10.005
更新日期:2014-12-01 00:00:00
abstract::CD45, the leucocyte common antigen, is a haemopoietic cell-specific tyrosine phosphatase. Many isoforms are generated by alternative splicing, but their function remains obscure. The extracellular domain of CD45 is highly polymorphic in all vertebrates. Importantly, human polymorphic variants that alter CD45 isoform e...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2006.01.001
更新日期:2006-03-01 00:00:00
abstract::Platelets are central players in thrombosis and hemostasis but are increasingly recognized as key components of the immune system. They shape ensuing immune responses by recruiting leukocytes, and support the development of adaptive immunity. Recent data shed new light on the complex role of platelets in immunity. Her...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2019.08.004
更新日期:2019-10-01 00:00:00