Abstract：
:Lymphocyte development has long served as an experimental paradigm, revealing fundamental mechanisms of gene regulation and cellular differentiation in mammals. The study of E-protein-mediated transcriptional regulation in lymphocyte development provides a means to address these mechanistic issues. Both genetic and biochemical studies have defined many important regulatory events during lymphocyte development that are mediated by E-proteins. The E2A gene, one of the three known E-protein genes in mammals, has a particularly important role in B-lymphocyte development. Major progress has been made in recent years towards understanding the physiological targets of E2A during B-lymphocyte development. Most notably, new insights have been gained regarding the role of E2A in controlling lineage commitment and V(D)J recombination. This Review focuses primarily on E2A-mediated gene regulation during B-lymphocyte development.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Lazorchak A,Jones ME,Zhuang Ydoi
10.1016/j.it.2005.03.011keywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
334-8issue
6eissn
1471-4906issn
1471-4981pii
S1471-4906(05)00082-7journal_volume
26pub_type
杂志文章,评审abstract：:Manipulating the immune system in order to induce clinically relevant responses against cancer is a longstanding goal. Interventions to enhance tumor-specific immunity through vaccination, sustaining effector T cell activation, or increasing the numbers of tumor-specific T cells using ex vivo expansion, have all resul...
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 评论,杂志文章
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更新日期：2019-11-01 00:00:00
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pub_type： 评论,杂志文章
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pub_type： 杂志文章,评审
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更新日期：2008-02-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2003-03-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2005.03.001
更新日期：2005-05-01 00:00:00
abstract：:The workshop on Multiple Sclerosis and Chemokines: Prospects for Therapeutic and Prophylactic Intervention was held in Chevy Chase, MD, USA, from 9-10 July 2001. ...
journal_title：Trends in immunology
pub_type：
doi：10.1016/s1471-4906(01)02056-7
更新日期：2001-11-01 00:00:00
