Understanding the structural dynamics of TCR-pMHC complex interactions.

Abstract:

:Dynamics plays an important but underappreciated role in the interaction between the T cell receptor (TCR) and peptide-bound major histocompatibility complex (pMHC). Crystallographic studies have provided key molecular insights into this interaction; however, due to inherent features of the structural approach, the image of TCR-pMHC interactions that has emerged is a static one. In this review, we discuss how molecular dynamics (MD) simulations can complement and extend current experimental methods aimed at examining TCR-pMHC dynamics. We review the insights obtained from studies that leverage MD approaches, and propose that an integrative strategy that harnesses both MD simulations and structural and biophysical methods will provide new inroads into understanding the transitory and dynamic molecular events that dictate TCR signaling and T cell activation.

journal_name

Trends Immunol

journal_title

Trends in immunology

authors

Kass I,Buckle AM,Borg NA

doi

10.1016/j.it.2014.10.005

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

604-612

issue

12

eissn

1471-4906

issn

1471-4981

pii

S1471-4906(14)00190-2

journal_volume

35

pub_type

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