Abstract：
:Mast cells are powerful immune modulators of the tissue microenvironment. Within seconds of activation, these cells release a variety of preformed biologically active products, followed by a wave of mediator synthesis and secretion. Increasing evidence suggests that an intricate network of inhibitory and activating receptors, specific signaling pathways, and adaptor proteins governs mast cell responsiveness to stimuli. Here, we discuss the biological and clinical relevance of negative and positive signaling modalities that control mast cell activation, with an emphasis on novel FcεRI regulators, immunoglobulin E (IgE)-independent pathways [e.g., Mas-related G protein-coupled receptor X2 (MRGPRX2)], tetraspanins, and the CD300 family of inhibitory and activating receptors.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Bulfone-Paus S,Nilsson G,Draber P,Blank U,Levi-Schaffer Fdoi
10.1016/j.it.2017.01.008subject
Has Abstractpub_date
2017-09-01 00:00:00pages
657-667issue
9eissn
1471-4906issn
1471-4981pii
S1471-4906(17)30022-4journal_volume
38pub_type
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