Immunotherapeutic gene transfer into muscle.

abstract：:Although therapy-mediated suppression of HIV-1 is effective and results in a degree of immune reconstitution, the complications resulting from life-long treatment emphasize the need for alternatives. This review discusses the use of structured interruptions in antiviral therapy to induce drug-free periods of immune-me...

journal_title：Trends in immunology

authors： Montaner LJ

更新日期：2001-02-01 00:00:00

abstract：:Recent studies have reported paradoxical roles of inflammation in tumor immunity triggered by PD-1 checkpoint antibody (Ab) blockade. Here, we elaborate on this controversy and propose a new perspective that might help understand this paradox. Since inflammatory cytokines and PD-1 blockade are known to target differen...

journal_title：Trends in immunology

authors： Hill M,Segovia M,Russo S,Girotti MR,Rabinovich GA

更新日期：2020-11-01 00:00:00

abstract：:Protection against pulmonary tuberculosis (TB) by vaccination is often ascribed to the presence of TB-reactive T cells in the lung before infection. Challenging this view, new studies analyzing vaccine-induced T cells in various tissue compartments after parenteral immunization suggest a poor correlation between the p...

journal_title：Trends in immunology

authors： Jeyanathan M,Heriazon A,Xing Z

更新日期：2010-07-01 00:00:00

abstract：:Chronic viral infections and cancer often lead to the emergence of dysfunctional or 'exhausted' CD8+ T cells, and the restoration of their functions is currently the focus of therapeutic interventions. In this review, we detail recent advances in the annotation of the gene modules and the epigenetic landscape associat...

journal_title：Trends in immunology

authors： Wang C,Singer M,Anderson AC

更新日期：2017-08-01 00:00:00

abstract：:Interactions between the T-cell receptor (TCR) and self-peptide-MHC (spMHC) have been hypothesized to modulate T-cell reactivity in the periphery. Recent studies examining CD4+ T-cell responses to spMHC class II describe apparently contradictory findings and arrive at opposite conclusions. One explanation for these se...

journal_title：Trends in immunology

authors： Ge Q,Bai A,Shen CH,Eisen HN,Chen J

更新日期：2003-04-01 00:00:00

abstract：:Recent advances allow aging-associated changes in B-cell function to be approached at a mechanistic level. Reduced expression of genes crucial to lineage commitment and differentiation yield diminished B-cell production. Moreover, intrinsic differences in the repertoire generated by B-cell precursors in aged individua...

journal_title：Trends in immunology

authors： Cancro MP,Hao Y,Scholz JL,Riley RL,Frasca D,Dunn-Walters DK,Blomberg BB

更新日期：2009-07-01 00:00:00

abstract：:Glioblastoma is an aggressive and incurable primary brain tumor. While the blockade of immune checkpoints leads to reversal of T cell exhaustion in many cancers, the efficacy of this therapy in glioblastoma requires further consideration of the brain microenvironment beyond T cell activity. Neural cells are crucially ...

journal_title：Trends in immunology

authors： Mirzaei R,Sarkar S,Yong VW

更新日期：2017-02-01 00:00:00

abstract：:An exemplar outcome of an immunology-based intervention is vaccine development; the current COVID-19 pandemic is a case in point. Can we build an immunology research ecosystem in Africa that nurtures discovery and enables translation? We see African immunologists as key agents of change and discuss obstacles and oppor...

journal_title：Trends in immunology

authors： Osier FHA,Mwandumba HC,Gray CM

更新日期：2020-12-01 00:00:00

abstract：:The immune system confines neoplasia at various stages of tumor development. Whereas the role of cellular immunity has been investigated widely and utilized in the clinic, the importance of humoral immunity in this process has begun to emerge only in recent years. Circulating antinuclear autoantibodies (ANAs) typicall...

journal_title：Trends in immunology

authors： Torchilin VP,Iakoubov LZ,Estrov Z

更新日期：2001-08-01 00:00:00

abstract：:To maintain prolonged colonization of the human gastric mucosa, Helicobacter pylori must avoid both innate and adaptive immune responses. During its long coexistence with humans, it has evolved complex strategies to maintain a mild inflammation of the gastric epithelium while limiting the extent of immune effector act...

journal_title：Trends in immunology

authors： Baldari CT,Lanzavecchia A,Telford JL

更新日期：2005-04-01 00:00:00

abstract：:Tetramethylpentadecane (TMPD, or commonly known as pristane)-induced lupus is a murine model of systemic lupus erythematosus (SLE). Renal disease and autoantibody production strictly depend on signaling through the interferon (IFN)-I receptor. The major source of IFN-I is immature monocytes bearing high levels of the ...

journal_title：Trends in immunology

authors： Reeves WH,Lee PY,Weinstein JS,Satoh M,Lu L

更新日期：2009-09-01 00:00:00

abstract：:The termination of inflammation is governed by endogenous molecules collectively referred to as 'mediators of resolution' of inflammation. There is now strong evidence to suggest that failed resolution may underpin autoimmune and inflammatory diseases and could thus be targeted to decrease inflammation. There are many...

journal_title：Trends in immunology

authors： Sugimoto MA,Vago JP,Perretti M,Teixeira MM

更新日期：2019-03-01 00:00:00

abstract：:At two checkpoints, T cell development is controlled by T cell receptor (TCR) signaling, which determines survival and lineage commitment. At the first of these checkpoints, signaling by the pre-TCR, the gammadeltaTCR or the alphabetaTCR has a major but nonexclusive impact on whether cells will become CD4-CD8- gammade...

journal_title：Trends in immunology

authors： Garbe AI,von Boehmer H

更新日期：2007-03-01 00:00:00

abstract：:Cyclically, during the day, increased permeability of the intestinal epithelial barrier, allowing nutrient uptake, must be compensated for, to achieve increased protection against potentially harmful components. Seillet et al. demonstrate that, upon food intake, enteric neuron-derived VIP promotes anticipatory mucosal...

journal_title：Trends in immunology

authors： Quatrini L,Moretta L,Mingari MC

更新日期：2020-05-01 00:00:00

abstract：:There is a growing body of evidence suggesting that bacterial signaling molecules are involved in cross-kingdom communication with eukaryotic cells. Bacterial signaling molecules can enter eukaryotic cells and appear to modulate immune responses to bacterial pathogens. Recently, an enticing study demonstrated that mam...

journal_title：Trends in immunology

authors： Sperandio V

更新日期：2004-10-01 00:00:00

abstract：:The innate immune system is the first line of defense against invading pathogens and is particularly important in warding off bacterial and viral infections presenting at the mucosal cell surface. From this primitive immune response, the more sophisticated adaptive immune system was derived. Despite nearly two decades...

journal_title：Trends in immunology

authors： Levy JA

更新日期：2001-06-01 00:00:00

abstract：:Despite extensive, recent research on the development of dendritic cells (DCs), their origin is a controversial issue in immunology, with important implications regarding their use in cancer immunotherapy. Although, under defined experimental conditions, DCs can be generated from myeloid or lymphoid precursors, the di...

journal_title：Trends in immunology

authors： Ardavín C,Martínez del Hoyo G,Martín P,Anjuère F,Arias CF,Marín AR,Ruiz S,Parrillas V,Hernández H

更新日期：2001-12-01 00:00:00

abstract：:The circadian system ensures the generation and maintenance of self-sustained ~24-h rhythms in physiology that are linked to internal and environmental changes. In mammals, daily variations in light intensity and other cues are integrated by a hypothalamic master clock that conveys circadian information to peripheral ...

journal_title：Trends in immunology

authors： Arjona A,Silver AC,Walker WE,Fikrig E

更新日期：2012-12-01 00:00:00

abstract：:Common variable immunodeficiency (CVID) is an immune disorder that not only causes increased susceptibility to infection, but also to inflammatory complications such as autoimmunity, lymphoid proliferation, malignancy, and granulomatous disease. Recent findings implicate the microbiome as a driver of this systemic imm...

journal_title：Trends in immunology

authors： Berbers RM,Nierkens S,van Laar JM,Bogaert D,Leavis HL

更新日期：2017-03-01 00:00:00

abstract：:Protease-activated receptors (PARs) belong to a family of G protein-coupled receptors activated by serine proteases via proteolytic cleavage. PARs are expressed on epithelial cells, endothelial cells, and leukocytes, indicating a role in controlling barrier function against external danger. During inflammation, microo...

journal_title：Trends in immunology

authors： Shpacovitch V,Feld M,Bunnett NW,Steinhoff M

更新日期：2007-12-01 00:00:00

abstract：:Nitrosation of thiol-containing proteins is a mechanism for cell regulation. Nitric-oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAIDs) are chemical entities obtained by adding a nitroxybutyl moiety to a conventional NSAID. NO-NSAIDs inhibit inflammation via cyclo-oxygenase (COX)-dependent and -independen...

journal_title：Trends in immunology

authors： Fiorucci S

更新日期：2001-05-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) induces a chronic generalized activation of the immune system, which plays an important role in the pathogenesis of AIDS. This ability of the virus might either be an evolved (adaptive) trait or a coincidental side effect of jumping to a new host species. We argue that selection favo...

journal_title：Trends in immunology

authors： Bartha I,Simon P,Müller V

更新日期：2008-07-01 00:00:00

abstract：:Toll-like receptors (TLRs) are primordial pathogen-recognition proteins that function as sentinels for the innate immune system. One of the TLR mysteries relates to TLR11, a receptor present in mice, but not humans, and known to recognize uropathogenic Escherichia coli. The first defined ligand for TLR11 has now been ...

journal_title：Trends in immunology

authors： Lauw FN,Caffrey DR,Golenbock DT

更新日期：2005-10-01 00:00:00

abstract：:Immune 'checkpoint' inhibitors can increase the activity of tumor-resident cytotoxic lymphocytes and have revolutionized cancer treatment. Current therapies block inhibitory pathways in tumor-infiltrating CD8+ T cells and recent studies have shown similar programs in other effector populations such as natural killer (...

journal_title：Trends in immunology

authors： Souza-Fonseca-Guimaraes F,Cursons J,Huntington ND

更新日期：2019-02-01 00:00:00

abstract：:T cells are subject to tight regulatory measures, as uncontrolled responses might be detrimental to the host. Control measures include central or thymic tolerance, and peripheral tolerance mechanisms acting after naive T cells have encountered their cognate antigen, such as anergy induction, the contraction phase (whe...

journal_title：Trends in immunology

authors： Bangs SC,McMichael AJ,Xu XN

更新日期：2006-11-01 00:00:00

abstract：:In autoimmune disease, a network of diverse cytokines is produced in association with disease susceptibility to constitute the 'cytokine milieu' that drives chronic inflammation. It remains elusive how cytokines interact in such a complex network to sustain inflammation in autoimmune disease. This has presented huge c...

journal_title：Trends in immunology

authors： Liu X,Fang L,Guo TB,Mei H,Zhang JZ

更新日期：2013-03-01 00:00:00

abstract：:T cells have an amazing ability to discern and differentially respond to MHC-embedded peptides that can differ by only a single amino acid. This potential involves a combination of the precise ligand-binding specificities of the T-cell receptor (TCR) and the distinct intracellular signaling processes it transmits. Sig...

journal_title：Trends in immunology

authors： Pitcher LA,van Oers NS

更新日期：2003-10-01 00:00:00

abstract：:Caspase recruitment domain-containing protein (Card)9 is a nonredundant adapter protein that functions in the innate immune system in the assembly of multifunctional signaling complexes. Together with B cell lymphoma (Bcl)10 and the paracaspase, mucosa-associated lymphoid tissue lymphoma translocation protein (Malt)1,...

journal_title：Trends in immunology

authors： Roth S,Ruland J

更新日期：2013-06-01 00:00:00

abstract：:Although the function of the circulating immune cell compartment has been studied in detail for decades, limitations in terms of access and cell yields from peripheral tissues have restricted our understanding of tissue-based immunity, particularly in humans. Recent advances in high-throughput protein analyses, transc...

journal_title：Trends in immunology

authors： Meininger I,Carrasco A,Rao A,Soini T,Kokkinou E,Mjösberg J

更新日期：2020-10-01 00:00:00

abstract：:Recent studies have indicated that complement proteins might exert novel functions that are distinct from their well-established inflammatory role, by modulating cellular responses and cell-cell interactions that are crucial to early development and cell differentiation. Accumulating evidence suggests that complement ...

journal_title：Trends in immunology

authors： Mastellos D,Lambris JD

更新日期：2002-10-01 00:00:00