Abstract:
:Recent studies have indicated that complement proteins might exert novel functions that are distinct from their well-established inflammatory role, by modulating cellular responses and cell-cell interactions that are crucial to early development and cell differentiation. Accumulating evidence suggests that complement might have important roles in diverse biologic processes, ranging from early hematopoiesis to skeletal and vascular development and normal reproduction. Furthermore, it is now becoming evident that complement-regulated pathways interact with other signaling networks and influence the outcome of complex developmental programs, such as limb regeneration in lower vertebrates and organ regeneration in mammals. These findings highlight a previously under-appreciated role of complement and might have important implications in the context of normal development by helping to elucidate the rather obscure role of innate immunity in such cell modulatory pathways.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Mastellos D,Lambris JDdoi
10.1016/s1471-4906(02)02287-1keywords:
subject
Has Abstractpub_date
2002-10-01 00:00:00pages
485-91issue
10eissn
1471-4906issn
1471-4981pii
S1471490602022871journal_volume
23pub_type
杂志文章,评审abstract::Plasma cells operate as factories where large quantities of Ig heavy and light chains are made and assembled into functional antibodies. The finished products are shipped out with impressive efficiency. A major component of the machinery necessary for high-rate antibody secretion is an elaborate network of endoplasmic...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2003.11.004
更新日期:2004-01-01 00:00:00
abstract::Oral tolerance is a well-characterized phenomenon in animals and is highly effective when induced as a treatment for experimental autoimmune disease. However, its use as a therapeutic modality for the treatment of autoimmune disease in humans has been disappointing. Much of the rationale for its use in humans is based...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(01)01892-0
更新日期:2001-05-01 00:00:00
abstract::Recent advances in genome analysis have provided important insights into the genetic architecture of infectious and inflammatory diseases. The combined analysis of loci detected by genome-wide association studies (GWAS) in 22 inflammatory diseases has revealed a shared genetic core and associated biochemical pathways ...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2015.12.006
更新日期:2016-02-01 00:00:00
abstract::Unlike T cells that recognize digested peptides, B cells recognize their cognate antigen in its native form. The B cell receptor used in recognition can also be secreted to bind to antigens and initiate multiple effector functions such as phagocytosis, complement activation, or neutralization of receptors. While B cel...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2016.10.003
更新日期:2016-12-01 00:00:00
abstract::Hepatitis C virus (HCV) uses complex and unique mechanisms to prevent, evade or subvert innate and adaptive immune responses and to establish persistent infection and chronic hepatitis. Recently developed experimental systems have significantly facilitated the analysis of HCV replication, virus-host interaction and pa...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(03)00178-9
更新日期:2003-08-01 00:00:00
abstract::Protease-activated receptors (PARs) belong to a family of G protein-coupled receptors activated by serine proteases via proteolytic cleavage. PARs are expressed on epithelial cells, endothelial cells, and leukocytes, indicating a role in controlling barrier function against external danger. During inflammation, microo...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2007.09.001
更新日期:2007-12-01 00:00:00
abstract::Lymph nodes are strategically located throughout the body to allow lymphocytes to efficiently encounter their cognate antigen and become activated. The structure of the lymph nodes is such that B and T lymphocytes each have their own microdomain. This structure is provided by lymph node stromal cells, which also provi...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2011.10.006
更新日期:2012-06-01 00:00:00
abstract::Activation-Induced cytidine Deaminase (AID) initiates affinity maturation and isotype switching by deaminating deoxycytidines within immunoglobulin genes, leading to somatic hypermutation (SHM) and class switch recombination (CSR). AID thus potentiates the humoral response to clear pathogens. Marking the 20th annivers...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2020.04.009
更新日期:2020-07-01 00:00:00
abstract::Protection against pulmonary tuberculosis (TB) by vaccination is often ascribed to the presence of TB-reactive T cells in the lung before infection. Challenging this view, new studies analyzing vaccine-induced T cells in various tissue compartments after parenteral immunization suggest a poor correlation between the p...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2010.05.002
更新日期:2010-07-01 00:00:00
abstract::House dust mites (HDM; Dermatophagoides sp.) are one of the commonest aeroallergens worldwide and up to 85% of asthmatics are typically HDM allergic. Allergenicity is associated both with the mites themselves and with ligands derived from mite-associated bacterial and fungal products. Murine models of allergic airways...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2011.06.006
更新日期:2011-09-01 00:00:00
abstract::CD45, the leucocyte common antigen, is a haemopoietic cell-specific tyrosine phosphatase. Many isoforms are generated by alternative splicing, but their function remains obscure. The extracellular domain of CD45 is highly polymorphic in all vertebrates. Importantly, human polymorphic variants that alter CD45 isoform e...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2006.01.001
更新日期:2006-03-01 00:00:00
abstract::T cells are subject to tight regulatory measures, as uncontrolled responses might be detrimental to the host. Control measures include central or thymic tolerance, and peripheral tolerance mechanisms acting after naive T cells have encountered their cognate antigen, such as anergy induction, the contraction phase (whe...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2006.09.006
更新日期:2006-11-01 00:00:00
abstract::NLRP6, a member of the nucleotide-binding domain, leucine-rich repeat-containing (NLR) innate immune receptor family, regulates inflammation and host defense against microorganisms. Similar to other NLRs, NLRP6 not only participates in inflammasome formation, but is also involved in nuclear factor-κB (NF-κB) and mitog...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2017.01.001
更新日期:2017-04-01 00:00:00
abstract::Genomic-scale gene expression profiling can reveal cellular physiology with unprecedented richness. This technology is being used to define the gene expression targets of individual regulatory proteins and signaling pathways. Comprehensive databases of gene expression measurements can be used to understand the patholo...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(00)01792-0
更新日期:2001-01-01 00:00:00
abstract::To maintain prolonged colonization of the human gastric mucosa, Helicobacter pylori must avoid both innate and adaptive immune responses. During its long coexistence with humans, it has evolved complex strategies to maintain a mild inflammation of the gastric epithelium while limiting the extent of immune effector act...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2005.01.007
更新日期:2005-04-01 00:00:00
abstract::Adult neurogenesis plays an important role in brain function and declines with aging. A recent report demonstrates clonal T cell expansion within neurogenic niches of the aged brain, impairing neurogenesis through IFNγ signaling (Dulken et al.,Nature, 2019). These results highlight T cells as important contributors to...
journal_title:Trends in immunology
pub_type: 评论,杂志文章
doi:10.1016/j.it.2019.07.007
更新日期:2019-09-01 00:00:00
abstract::NOD1 and NOD2 are pattern recognition receptors of the innate immune system with well-established roles in sensing fragments of bacterial peptidoglycan. In addition to their role as microbial sensors, recent evidence indicates that nucleotide-binding oligomerization domains (NODs) can also recognize a broader array of...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2017.07.004
更新日期:2017-10-01 00:00:00
abstract::Mammalian group 2 innate lymphoid cells (ILC2s) are responsible for the early production of type 2 cytokines at mucosal barriers upon exposure to allergen. Inflammatory tissue environmental cues can influence ILC2 activity, and this cellular population can be further categorized into subtypes with additional or altern...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2019.10.007
更新日期:2019-12-01 00:00:00
abstract::Three recent studies provide new insight into the mechanisms that promote the differentiation of antigen-primed T cells into the follicular helper T (Tfh) lineage, revealing a key role for the transcription factor TCF-1 in the regulation of the Bcl6-Blimp-1 axis that mediates the divergence between the Tfh and the Th1...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2015.11.001
更新日期:2015-12-01 00:00:00
abstract::Autophagy is an evolutionarily conserved homeostatic process by which cells deliver cytoplasmic material for degradation into lysosomes. Autophagy may have evolved as a nutrient-providing homeostatic pathway induced upon starvation, but with the acquisition of cargo receptors, autophagy has become an important cellula...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2012.06.003
更新日期:2012-10-01 00:00:00
abstract::Evolutionarily, how RAG endonucleases in vertebrate immune systems could shed dangerous transposon-like propensities, and instead, support the organized assembly of antigen receptor variable domains, has been unclear. Recent structural work by Schatz and colleagues (Nature, 2019) identifies features of the RAG endonuc...
journal_title:Trends in immunology
pub_type: 评论,杂志文章
doi:10.1016/j.it.2019.06.007
更新日期:2019-08-01 00:00:00
abstract::Two recent crystal structures of membrane attack complex/perforin (MACPF) domains found in the complement and perforin families unexpectedly reveal that some proteins of the immune system share a common core fold with their bacterial targets. Although a relationship between MACPF proteins and the previously characteri...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2007.11.003
更新日期:2008-02-01 00:00:00
abstract::Lung capillaries, best known for vital gas exchange, also contribute to neutrophil margination, a phenomenon resulting in large numbers of pulmonary vascular neutrophils. Importantly, the functional relevance of neutrophil margination is unknown. Recent advances in microscopy have altered our understanding of why neut...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2018.09.002
更新日期:2018-11-01 00:00:00
abstract::In clinical practice, a successful patient-physician partnership can improve the outcome of treatment, especially in cases of chronic disease or cancer. To establish this partnership, physicians must explain treatment options and potential outcomes, but how to best do this when treatment is based on scientific princip...
journal_title:Trends in immunology
pub_type: 历史文章,杂志文章
doi:10.1016/j.it.2016.04.005
更新日期:2016-06-01 00:00:00
abstract::An exemplar outcome of an immunology-based intervention is vaccine development; the current COVID-19 pandemic is a case in point. Can we build an immunology research ecosystem in Africa that nurtures discovery and enables translation? We see African immunologists as key agents of change and discuss obstacles and oppor...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2020.10.007
更新日期:2020-12-01 00:00:00
abstract::Recent studies have reported paradoxical roles of inflammation in tumor immunity triggered by PD-1 checkpoint antibody (Ab) blockade. Here, we elaborate on this controversy and propose a new perspective that might help understand this paradox. Since inflammatory cytokines and PD-1 blockade are known to target differen...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2020.09.003
更新日期:2020-11-01 00:00:00
abstract::Immune suppression by T(reg) cells must be overcome to mount robust and effective anti-pathogen immune responses. A new paper in Immunity from Medzhitov and colleagues shows that IL-1-dependent activation of MyD88 promotes the development of Th1 cells by rendering them impervious to T(reg) cell-mediated inhibition. ...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2014.02.001
更新日期:2014-03-01 00:00:00
abstract::One major determinant of systemic immunity during homeostasis and in certain complex multifactorial diseases (e.g. cancer and autoimmune conditions), is the gut microbiota. These commensals can shape systemic immune responses via translocation of metabolites, microbial cell wall components, and viable microbes. In the...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2020.12.005
更新日期:2021-02-01 00:00:00
abstract::The 2009 influenza pandemic highlighted the threat that type A influenza poses to human health. Thus, there is an urgency to understand the pathobiology of influenza infection and the contribution of the host immune response to virus elimination and the development of lung injury. This review focuses on the T cell arm...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2011.02.006
更新日期:2011-05-01 00:00:00
abstract::In lymphatic tissue, professional antigen-presenting cells (APCs) such as dendritic cells (DCs), mature after sensing microbe-associated molecular patterns (MAMPs) by pattern recognition receptors (PRRs), and subsequently activate T cell immunity. Non-pathogenic MAMPs, derived for example from commensal bacteria, are ...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2010.06.001
更新日期:2010-08-01 00:00:00