Abstract：
:With the identification of T helper (Th)17 cells, a specific subset of CD4 T cells expressing interleukin (IL)-17 and IL-22, research on the function of these cytokines initially largely focused on traditional adaptive immune responses. However, IL-17 and IL-22 enhance basic innate barrier defenses at mucosal surfaces, such as antimicrobial peptide production and neutrophil recruitment; both events that occur rapidly and precede adaptive phase immunity. At the intestinal mucosal surface, it is now clear that innate lymphoid cells are also important sources of IL-17 and IL-22 during early phases of infection. Here, we discuss the function of innate IL-17- and IL-22-producing lymphocytes during enteric bacterial infection and their regulation by the intestinal microbiota, Toll-like receptors (TLRs) and Nod-like receptors (NLRs).
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Rubino SJ,Geddes K,Girardin SEdoi
10.1016/j.it.2012.01.003subject
Has Abstractpub_date
2012-03-01 00:00:00pages
112-8issue
3eissn
1471-4906issn
1471-4981pii
S1471-4906(12)00004-Xjournal_volume
33pub_type
杂志文章,评审abstract：:Three recent studies provide new insight into the mechanisms that promote the differentiation of antigen-primed T cells into the follicular helper T (Tfh) lineage, revealing a key role for the transcription factor TCF-1 in the regulation of the Bcl6-Blimp-1 axis that mediates the divergence between the Tfh and the Th1...
journal_title：Trends in immunology
pub_type： 杂志文章
doi：10.1016/j.it.2015.11.001
更新日期：2015-12-01 00:00:00
abstract：:A prominent population of innate CD8+ T cells develops in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3. These cells have the phenotype and function of memory CD8+ T cells, without previous exposure to antigen. Surprisingly, the cytokine IL-4 plays a key role in their development...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2010.12.004
更新日期：2011-02-01 00:00:00
abstract：:Hepatitis C virus (HCV) uses complex and unique mechanisms to prevent, evade or subvert innate and adaptive immune responses and to establish persistent infection and chronic hepatitis. Recently developed experimental systems have significantly facilitated the analysis of HCV replication, virus-host interaction and pa...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(03)00178-9
更新日期：2003-08-01 00:00:00
abstract：:House dust mites (HDM; Dermatophagoides sp.) are one of the commonest aeroallergens worldwide and up to 85% of asthmatics are typically HDM allergic. Allergenicity is associated both with the mites themselves and with ligands derived from mite-associated bacterial and fungal products. Murine models of allergic airways...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2011.06.006
更新日期：2011-09-01 00:00:00
abstract：:T-bet was originally described as the key transcription factor defining type 1 T helper (Th) cells. However, it is now clear that it drives the orchestrated generation of effector and memory cells in multiple different lymphocyte lineages. In addition to Th1 cells, CD8 T cells, B cells and some innate lymphocyte popul...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2017.02.003
更新日期：2017-04-01 00:00:00
abstract：:Recent studies have indicated that complement proteins might exert novel functions that are distinct from their well-established inflammatory role, by modulating cellular responses and cell-cell interactions that are crucial to early development and cell differentiation. Accumulating evidence suggests that complement ...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(02)02287-1
更新日期：2002-10-01 00:00:00
abstract：:Systemic sclerosis (SSc, also known as scleroderma) has the highest case-specific mortality among the rheumatic diseases; however, advances in understanding of pathogenesis and an appreciation of the clinical heterogeneity of this disease, together with therapeutic advances in other areas, have raised the possibility ...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2005.09.002
更新日期：2005-11-01 00:00:00
abstract：:Nitrosation of thiol-containing proteins is a mechanism for cell regulation. Nitric-oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAIDs) are chemical entities obtained by adding a nitroxybutyl moiety to a conventional NSAID. NO-NSAIDs inhibit inflammation via cyclo-oxygenase (COX)-dependent and -independen...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(01)01904-4
更新日期：2001-05-01 00:00:00
abstract：:Homodimeric antibodies devoid of light chains have evolved multiple times through convergent evolution, yet their specific immunological functions remain poorly understood. We survey the molecular and structural features of these antibodies, their immunological functions in host defense, and reflect on the long-standi...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2018.09.008
更新日期：2018-12-01 00:00:00
abstract：:Helminth parasites survive through a combination of parasite longevity, repeated re-infection and selective immune suppression to prevent protective Th2 responses. To counteract helminth-induced immunosuppression, and to induce long-term immunological memory, understanding of the multiple regulatory pathways within th...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2012.01.001
更新日期：2012-04-01 00:00:00
abstract：:Much attention has focused on the role of co-stimulation in dictating tolerance versus immunity to internalized antigens, with the assumption that the presentation of antigen-derived peptides by MHC molecules occurs constitutively. Here, I highlight our new appreciation for the regulated presentation of phagocytosed a...
journal_title：Trends in immunology
pub_type： 杂志文章
doi：10.1016/j.it.2006.11.001
更新日期：2007-01-01 00:00:00
abstract：:Cell migration is crucial for intrathymic T-cell differentiation. Chemokines and extracellular matrix proteins per se induce thymocyte migration, and recent data suggest a combinatorial role for these molecules in this event. For example, thymocyte migration induced by fibronectin plus CXCL12/SDF1-alpha (stromal cell-...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(02)02224-x
更新日期：2002-06-01 00:00:00
abstract：:The ability of a primary challenge to protect against secondary infection (e.g., during vaccination) independent of the adaptive immune system is mediated in part by macrophage 'training'. Two new studies show that macrophage training is associated with genome-wide epigenetic changes and is regulated by the mTOR pathw...
journal_title：Trends in immunology
pub_type： 信件
doi：10.1016/j.it.2014.11.004
更新日期：2015-01-01 00:00:00
abstract：:Despite extensive, recent research on the development of dendritic cells (DCs), their origin is a controversial issue in immunology, with important implications regarding their use in cancer immunotherapy. Although, under defined experimental conditions, DCs can be generated from myeloid or lymphoid precursors, the di...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(01)02059-2
更新日期：2001-12-01 00:00:00
abstract：:Toll-like receptors (TLRs) are sensors of foreign microbial products, which initiate host defense responses in all multicellular organisms examined to date. They are the target for most adjuvants, are essential for the establishment of memory in T and B cells and provoke inflammation. They program dendritic cells in t...
journal_title：Trends in immunology
pub_type： 传,历史文章,杂志文章,评审
doi：10.1016/j.it.2004.10.005
更新日期：2004-12-01 00:00:00
abstract：:The entry of exogenous antigen into the MHC class I-restricted cross-presentation pathway can contribute to CD8(+) T cell tolerance and immunity, in particular to peripheral self-antigens or selected viruses and bacteria showing restricted tissue tropism. Dendritic cells are the key cross-presenting cells and, as such...
journal_title：Trends in immunology
pub_type： 杂志文章
doi：10.1016/j.it.2006.12.008
更新日期：2007-02-01 00:00:00
abstract：:The 2009 influenza pandemic highlighted the threat that type A influenza poses to human health. Thus, there is an urgency to understand the pathobiology of influenza infection and the contribution of the host immune response to virus elimination and the development of lung injury. This review focuses on the T cell arm...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2011.02.006
更新日期：2011-05-01 00:00:00
abstract：:Natural killer (NK)-cell receptors (NKRs) on CD8+ T cells can modulate antigen-specific T-cell activity but their function and rules that govern their expression remain unclear. Recent work has provided new insight into CD94-NKG2A expression on T cells. Whereas upregulation on the cell surface is induced following T-c...
journal_title：Trends in immunology
pub_type： 杂志文章
doi：10.1016/s1471-4906(03)00064-4
更新日期：2003-04-01 00:00:00
abstract：:Whether MHC restriction by the T cell receptor (TCR) is a product of evolutionary pressures leading to germline-encoded 'rules of engagement' remains avidly debated. Structural results derived from analysis of TCR-peptide-MHC complexes appear to support a model of physical specificity between TCR germline V regions an...
journal_title：Trends in immunology
pub_type： 杂志文章
doi：10.1016/j.it.2012.05.005
更新日期：2012-09-01 00:00:00
abstract：:NLRP6, a member of the nucleotide-binding domain, leucine-rich repeat-containing (NLR) innate immune receptor family, regulates inflammation and host defense against microorganisms. Similar to other NLRs, NLRP6 not only participates in inflammasome formation, but is also involved in nuclear factor-κB (NF-κB) and mitog...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2017.01.001
更新日期：2017-04-01 00:00:00
abstract：:Common variable immunodeficiency (CVID) is an immune disorder that not only causes increased susceptibility to infection, but also to inflammatory complications such as autoimmunity, lymphoid proliferation, malignancy, and granulomatous disease. Recent findings implicate the microbiome as a driver of this systemic imm...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2016.11.008
更新日期：2017-03-01 00:00:00
abstract：:The full potential of T cell-based immunotherapies remains limited by a variety of T cell extrinsic and intrinsic immunosuppressive mechanisms that can become imprinted to stably reduce the antitumor ability of T cells. Here, we discuss recent insights into memory CD8+ T cell differentiation and exhaustion and the ass...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2020.06.008
更新日期：2020-08-01 00:00:00
abstract：:The mechanisms accounting for the protective role of endogenous interferon gamma (IFN-gamma) in certain murine autoimmune disease models, versus a disease-promoting role in others, have remained elusive. The protective effect of IFN-gamma might be unique to models that rely on the use of complete Freund's adjuvant (CF...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(01)01937-8
更新日期：2001-07-01 00:00:00
abstract：:Microglia are brain macrophages that emerge from early erythro-myeloid precursors in the embryonic yolk sac and migrate to the brain mesenchyme before the blood brain barrier is formed. They seed the brain, and proliferate until they have formed a grid-like distribution in the central nervous system that is maintained...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2015.08.005
更新日期：2015-10-01 00:00:00
abstract：:Interactions between the T-cell receptor (TCR) and self-peptide-MHC (spMHC) have been hypothesized to modulate T-cell reactivity in the periphery. Recent studies examining CD4+ T-cell responses to spMHC class II describe apparently contradictory findings and arrive at opposite conclusions. One explanation for these se...
journal_title：Trends in immunology
pub_type： 杂志文章
doi：10.1016/s1471-4906(03)00060-7
更新日期：2003-04-01 00:00:00
abstract：:Mast cells play a central role in the initiation of inflammatory responses associated with asthma and other allergic disorders. Receptor-mediated mast cell growth, differentiation, homing to their target tissues, survival and activation are all controlled, to varying degrees, by phosphoinositide-3-kinase (PI3K)-driven...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2008.07.004
更新日期：2008-10-01 00:00:00
abstract：:Two studies show that adding NOTCH ligands to Flt3L cultures increases the yield of cDC1s from mouse and human progenitors. Moreover, these NOTCH-DCs more closely resemble in vivo DCs transcriptionally and functionally. This will be extremely valuable for studying DCs in vitro and for further developing autologous DC-...
journal_title：Trends in immunology
pub_type： 评论,杂志文章
doi：10.1016/j.it.2018.08.002
更新日期：2018-10-01 00:00:00
abstract：:Beyond their role in neutralization, antibodies mediate functions such as phagocytosis, cytotoxicity, and maintenance of immune homeostasis. Two modifications to the constant domain control antibody activity: theirreversible genomic selection of isotype/subclass and alterations in glycosylation. Because glycosylation ...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2017.02.004
更新日期：2017-05-01 00:00:00
abstract：:Oral tolerance is a well-characterized phenomenon in animals and is highly effective when induced as a treatment for experimental autoimmune disease. However, its use as a therapeutic modality for the treatment of autoimmune disease in humans has been disappointing. Much of the rationale for its use in humans is based...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(01)01892-0
更新日期：2001-05-01 00:00:00
abstract：:Caspase recruitment domain-containing protein (Card)9 is a nonredundant adapter protein that functions in the innate immune system in the assembly of multifunctional signaling complexes. Together with B cell lymphoma (Bcl)10 and the paracaspase, mucosa-associated lymphoid tissue lymphoma translocation protein (Malt)1,...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2013.02.006
更新日期：2013-06-01 00:00:00
