Abstract:
:Mast cells play a central role in the initiation of inflammatory responses associated with asthma and other allergic disorders. Receptor-mediated mast cell growth, differentiation, homing to their target tissues, survival and activation are all controlled, to varying degrees, by phosphoinositide-3-kinase (PI3K)-driven pathways. It is not fully understood how such diverse responses can be differentially regulated by PI3K. However, recent studies have provided greater insight into the mechanisms that control, and those that are controlled by, different PI3K subunit isoforms in mast cells. In this review, we discuss how PI3K influences the mast cell processes described above. Furthermore, we describe how different mast cell receptors use alternative isoforms of PI3K for these functions and discuss potential downstream targets of these isoforms.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Kim MS,Rådinger M,Gilfillan AMdoi
10.1016/j.it.2008.07.004subject
Has Abstractpub_date
2008-10-01 00:00:00pages
493-501issue
10eissn
1471-4906issn
1471-4981pii
S1471-4906(08)00201-9journal_volume
29pub_type
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journal_title:Trends in immunology
pub_type: 评论,杂志文章
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doi:10.1016/j.it.2013.02.006
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journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2011.07.003
更新日期:2011-11-01 00:00:00
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doi:10.1016/j.it.2003.08.003
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更新日期:2001-12-01 00:00:00
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doi:10.1016/j.it.2010.06.001
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pub_type: 杂志文章,评审
doi:10.1016/j.it.2012.11.001
更新日期:2013-05-01 00:00:00
abstract::Mast cells are currently recognized as effector cells in many settings beyond just allergic reactions, including innate immunity, autoimmunity, chronic inflammatory disorders and atherosclerosis. Signaling pathways of the mast cell response have been widely explored in the past but these are still linked with single a...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2007.06.007
更新日期:2007-08-01 00:00:00