Abstract：
:Homodimeric antibodies devoid of light chains have evolved multiple times through convergent evolution, yet their specific immunological functions remain poorly understood. We survey the molecular and structural features of these antibodies, their immunological functions in host defense, and reflect on the long-standing question of the evolutionary forces driving their emergence.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Brooks CL,Rossotti MA,Henry KAdoi
10.1016/j.it.2018.09.008subject
Has Abstractpub_date
2018-12-01 00:00:00pages
956-960issue
12eissn
1471-4906issn
1471-4981pii
S1471-4906(18)30184-4journal_volume
39pub_type
杂志文章,评审abstract：:To maintain prolonged colonization of the human gastric mucosa, Helicobacter pylori must avoid both innate and adaptive immune responses. During its long coexistence with humans, it has evolved complex strategies to maintain a mild inflammation of the gastric epithelium while limiting the extent of immune effector act...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
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abstract：:The MHC class II transcriptional activator (CIITA) is the major regulator of expression of MHC class II genes. Thus, CIITA plays a fundamental role in the regulation of the immune response. Here, we discuss our findings on the dual role of CIITA during infections, as the target (prey) for certain pathogens but the hos...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(01)02003-8
更新日期：2001-10-01 00:00:00
abstract：:In lymphatic tissue, professional antigen-presenting cells (APCs) such as dendritic cells (DCs), mature after sensing microbe-associated molecular patterns (MAMPs) by pattern recognition receptors (PRRs), and subsequently activate T cell immunity. Non-pathogenic MAMPs, derived for example from commensal bacteria, are ...
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2007.11.003
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2020-06-01 00:00:00
abstract：:Indoleamine 2,3-dioxygenase (IDO) has immunoregulatory roles associated with tryptophan metabolism. These include counter-regulation (controlling inflammation) and acquired tolerance in T cells. Recent findings reveal that IDO can be triggered by innate responses during tumorigenesis, and also by attempted T cell acti...
journal_title：Trends in immunology
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2003.10.008
更新日期：2003-12-01 00:00:00
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journal_title：Trends in immunology
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2016-03-01 00:00:00
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journal_title：Trends in immunology
pub_type： 评论,杂志文章
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更新日期：2019-08-01 00:00:00
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journal_title：Trends in immunology
pub_type： 历史文章,杂志文章
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更新日期：2016-06-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2019.11.004
更新日期：2020-01-01 00:00:00
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journal_title：Trends in immunology
pub_type： 评审
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更新日期：2014-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2001-11-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章
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更新日期：2003-04-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2006-03-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
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更新日期：2011-03-01 00:00:00
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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更新日期：2014-03-01 00:00:00
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journal_title：Trends in immunology
pub_type： 新闻
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2011-02-01 00:00:00
abstract：:Interleukin-1β (IL-1β) and IL-18 contribute to host defense against infection by augmenting antimicrobial properties of phagocytes and initiating Th1 and Th17 adaptive immune responses. Protein complexes called inflammasomes activate intracellular caspase-1 autocatalytically, which cleaves the inactive precursors of I...
journal_title：Trends in immunology
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journal_title：Trends in immunology
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doi：10.1016/j.it.2019.08.004
更新日期：2019-10-01 00:00:00
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journal_title：Trends in immunology
pub_type： 评论,杂志文章
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(01)02059-2
更新日期：2001-12-01 00:00:00
