Abstract:
:Evolutionarily, how RAG endonucleases in vertebrate immune systems could shed dangerous transposon-like propensities, and instead, support the organized assembly of antigen receptor variable domains, has been unclear. Recent structural work by Schatz and colleagues (Nature, 2019) identifies features of the RAG endonuclease deemed to be key in supporting this critical change in vertebrate advancement.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Lieber MRdoi
10.1016/j.it.2019.06.007subject
Has Abstractpub_date
2019-08-01 00:00:00pages
668-670issue
8eissn
1471-4906issn
1471-4981pii
S1471-4906(19)30132-2journal_volume
40pub_type
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doi:10.1016/s1471-4906(01)02059-2
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journal_title:Trends in immunology
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abstract::Immuno-gene therapy can be advantageously performed with nonviral approaches. Genes that encode regulatory cytokines or inflammatory cytokine inhibitors can be delivered intramuscularly and expressed for weeks or months. This type of gene transfer into muscle has been shown to ameliorate several autoimmune diseases an...
journal_title:Trends in immunology
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doi:10.1016/s1471-4906(00)01822-6
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abstract::Inducing sustained, robust CD8(+) T cell responses is necessary for therapeutic intervention in chronic infectious diseases and cancer. Unfortunately, most adjuvant formulations fail to induce substantial cellular immunity in humans. Attenuated acute infectious agents induce strong CD8(+) T cell immunity, and are thou...
journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(01)01937-8
更新日期:2001-07-01 00:00:00
abstract::With the identification of T helper (Th)17 cells, a specific subset of CD4 T cells expressing interleukin (IL)-17 and IL-22, research on the function of these cytokines initially largely focused on traditional adaptive immune responses. However, IL-17 and IL-22 enhance basic innate barrier defenses at mucosal surfaces...
journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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doi:10.1016/j.it.2011.10.001
更新日期:2012-01-01 00:00:00
abstract::T cells have an amazing ability to discern and differentially respond to MHC-embedded peptides that can differ by only a single amino acid. This potential involves a combination of the precise ligand-binding specificities of the T-cell receptor (TCR) and the distinct intracellular signaling processes it transmits. Sig...
journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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doi:10.1016/j.it.2020.09.003
更新日期:2020-11-01 00:00:00
abstract::The recent Zika virus (ZIKV) epidemic has created an urgent need for a safe and effective vaccine. There is still a dearth of knowledge about ZIKV immunity, but years of investigation into the immunobiology of other flaviviruses has helped to accelerate the development of a ZIKV vaccine. Although the humoral immune re...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2017.05.004
更新日期:2017-08-01 00:00:00
abstract::Platelets are central players in thrombosis and hemostasis but are increasingly recognized as key components of the immune system. They shape ensuing immune responses by recruiting leukocytes, and support the development of adaptive immunity. Recent data shed new light on the complex role of platelets in immunity. Her...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2019.08.004
更新日期:2019-10-01 00:00:00
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abstract::Mammalian group 2 innate lymphoid cells (ILC2s) are responsible for the early production of type 2 cytokines at mucosal barriers upon exposure to allergen. Inflammatory tissue environmental cues can influence ILC2 activity, and this cellular population can be further categorized into subtypes with additional or altern...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2019.10.007
更新日期:2019-12-01 00:00:00
abstract::The 2009 influenza pandemic highlighted the threat that type A influenza poses to human health. Thus, there is an urgency to understand the pathobiology of influenza infection and the contribution of the host immune response to virus elimination and the development of lung injury. This review focuses on the T cell arm...
journal_title:Trends in immunology
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2019.01.007
更新日期:2019-03-01 00:00:00
abstract::γδ T lymphocytes are involved in the stress response to injured epithelia and in tissue homeostasis by limiting the dissemination of malignant or infected cells and by regulating the nature of the subsequent adaptive immune response. γδ T cells have potent MHC-unrestricted cytotoxicity, a high potential for cytokine r...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2012.01.006
更新日期:2012-05-01 00:00:00
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journal_title:Trends in immunology
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doi:10.1016/j.it.2017.01.008
更新日期:2017-09-01 00:00:00