Transposons to V(D)J Recombination: Evolution of the RAG Reaction.

Abstract:

:Evolutionarily, how RAG endonucleases in vertebrate immune systems could shed dangerous transposon-like propensities, and instead, support the organized assembly of antigen receptor variable domains, has been unclear. Recent structural work by Schatz and colleagues (Nature, 2019) identifies features of the RAG endonuclease deemed to be key in supporting this critical change in vertebrate advancement.

journal_name

Trends Immunol

journal_title

Trends in immunology

authors

Lieber MR

doi

10.1016/j.it.2019.06.007

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

668-670

issue

8

eissn

1471-4906

issn

1471-4981

pii

S1471-4906(19)30132-2

journal_volume

40

pub_type

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