Abstract：
:Recent advances in genome analysis have provided important insights into the genetic architecture of infectious and inflammatory diseases. The combined analysis of loci detected by genome-wide association studies (GWAS) in 22 inflammatory diseases has revealed a shared genetic core and associated biochemical pathways that play a central role in pathological inflammation. Parallel whole-exome sequencing studies have identified 265 genes mutated in primary immunodeficiencies (PID). Here, we examine the overlap between these two data sets, and find that it consists of genes essential for protection against infections and in which persistent activation causes pathological inflammation. Based on this intersection, we propose that, although strong or inactivating mutations (rare variants) in these genes may cause severe disease (PIDs), their more subtle modulation potentially by common regulatory/coding variants may contribute to chronic inflammation.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Fodil N,Langlais D,Gros Pdoi
10.1016/j.it.2015.12.006subject
Has Abstractpub_date
2016-02-01 00:00:00pages
126-140issue
2eissn
1471-4906issn
1471-4981pii
S1471-4906(15)00303-8journal_volume
37pub_type
杂志文章,评审abstract：:Over the years, the role of the eosinophil in asthma and allergic processes has been disputed. Recent human experiments using a humanised monoclonal antibody to interleukin-5 (IL-5), and animal studies involving specific IL-5 gene deletion, indicates that eosinophils might control downstream repair and remodelling pro...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2004.07.006
更新日期：2004-09-01 00:00:00
abstract：:Tetramethylpentadecane (TMPD, or commonly known as pristane)-induced lupus is a murine model of systemic lupus erythematosus (SLE). Renal disease and autoantibody production strictly depend on signaling through the interferon (IFN)-I receptor. The major source of IFN-I is immature monocytes bearing high levels of the ...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2009.06.003
更新日期：2009-09-01 00:00:00
abstract：:The 2009 influenza pandemic highlighted the threat that type A influenza poses to human health. Thus, there is an urgency to understand the pathobiology of influenza infection and the contribution of the host immune response to virus elimination and the development of lung injury. This review focuses on the T cell arm...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2011.02.006
更新日期：2011-05-01 00:00:00
abstract：:Three recent studies provide new insight into the mechanisms that promote the differentiation of antigen-primed T cells into the follicular helper T (Tfh) lineage, revealing a key role for the transcription factor TCF-1 in the regulation of the Bcl6-Blimp-1 axis that mediates the divergence between the Tfh and the Th1...
journal_title：Trends in immunology
pub_type： 杂志文章
doi：10.1016/j.it.2015.11.001
更新日期：2015-12-01 00:00:00
abstract：:A prominent population of innate CD8+ T cells develops in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3. These cells have the phenotype and function of memory CD8+ T cells, without previous exposure to antigen. Surprisingly, the cytokine IL-4 plays a key role in their development...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2010.12.004
更新日期：2011-02-01 00:00:00
abstract：:Inflammatory bowel diseases (IBDs) are chronic debilitating conditions, which impair the patient's quality of life significantly. Among them, Crohn's disease and ulcerative colitis are idiopathic disorders for which an infective etiology has long been sought. Here, we present an opinion in support of the hypothesis th...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(01)02000-2
更新日期：2001-09-01 00:00:00
abstract：:Nitrosation of thiol-containing proteins is a mechanism for cell regulation. Nitric-oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAIDs) are chemical entities obtained by adding a nitroxybutyl moiety to a conventional NSAID. NO-NSAIDs inhibit inflammation via cyclo-oxygenase (COX)-dependent and -independen...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(01)01904-4
更新日期：2001-05-01 00:00:00
abstract：:The signaling lymphocytic activation molecule (SLAM) and SLAM-associated protein (SAP) families have key roles in normal immunity. They have also been implicated in diseases such as immunodeficiencies and auto-immunity. However, recent findings raise issues requiring examination in future investigations of these molec...
journal_title：Trends in immunology
pub_type： 杂志文章
doi：10.1016/j.it.2006.03.003
更新日期：2006-05-01 00:00:00
abstract：:Amyloid formation contributes to the development of progressive metabolic and neurodegenerative diseases, while also serving functional roles in host defense. Emerging evidence suggests that as amyloidogenic peptides populate distinct aggregation states, they interact with different combinations of pattern recognition...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2019.06.005
更新日期：2019-08-01 00:00:00
abstract：:Inducing sustained, robust CD8(+) T cell responses is necessary for therapeutic intervention in chronic infectious diseases and cancer. Unfortunately, most adjuvant formulations fail to induce substantial cellular immunity in humans. Attenuated acute infectious agents induce strong CD8(+) T cell immunity, and are thou...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2016.01.001
更新日期：2016-03-01 00:00:00
abstract：:The F4/80 monoclonal antibody has been used widely as a marker for mouse macrophages. The antigen (Ag) recognized by the antibody has been characterized as a member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family, although the function of the molecule has remained elusive. A recent study provides evi...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2005.07.008
更新日期：2005-10-01 00:00:00
abstract：:T cells are subject to tight regulatory measures, as uncontrolled responses might be detrimental to the host. Control measures include central or thymic tolerance, and peripheral tolerance mechanisms acting after naive T cells have encountered their cognate antigen, such as anergy induction, the contraction phase (whe...
journal_title：Trends in immunology
pub_type： 杂志文章
doi：10.1016/j.it.2006.09.006
更新日期：2006-11-01 00:00:00
abstract：:Autophagy is an evolutionarily conserved homeostatic process by which cells deliver cytoplasmic material for degradation into lysosomes. Autophagy may have evolved as a nutrient-providing homeostatic pathway induced upon starvation, but with the acquisition of cargo receptors, autophagy has become an important cellula...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2012.06.003
更新日期：2012-10-01 00:00:00
abstract：:Whether MHC restriction by the T cell receptor (TCR) is a product of evolutionary pressures leading to germline-encoded 'rules of engagement' remains avidly debated. Structural results derived from analysis of TCR-peptide-MHC complexes appear to support a model of physical specificity between TCR germline V regions an...
journal_title：Trends in immunology
pub_type： 杂志文章
doi：10.1016/j.it.2012.05.005
更新日期：2012-09-01 00:00:00
abstract：:The recent Zika virus (ZIKV) epidemic has created an urgent need for a safe and effective vaccine. There is still a dearth of knowledge about ZIKV immunity, but years of investigation into the immunobiology of other flaviviruses has helped to accelerate the development of a ZIKV vaccine. Although the humoral immune re...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2017.05.004
更新日期：2017-08-01 00:00:00
abstract：:The understanding of tumor-host interactions remains elusive despite significant progress in the identification of tumor antigens (TAs) recognized by autologous T cells. In particular, most human tumors do not regress and continue to grow in spite of spontaneous or immunization-induced immune responses demonstrated in...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(03)00116-9
更新日期：2003-06-01 00:00:00
abstract：:Epstein-Barr Virus (EBV) is one of the most successful human viruses, infecting more than 90% of the adult population worldwide and persisting for the lifetime of the host. Individuals with a history of symptomatic primary EBV infection, called infectious mononucleosis, carry a moderately higher risk of developing mul...
journal_title：Trends in immunology
pub_type： 杂志文章
doi：10.1016/j.it.2009.03.007
更新日期：2009-06-01 00:00:00
abstract：:Recent epidemiological studies have shown that, in addition to disease-specific effects, vaccines against infectious diseases have nonspecific effects on the ability of the immune system to handle other pathogens. For instance, in randomized trials tuberculosis and measles vaccines are associated with a substantial re...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2013.04.004
更新日期：2013-09-01 00:00:00
abstract：:Despite extensive, recent research on the development of dendritic cells (DCs), their origin is a controversial issue in immunology, with important implications regarding their use in cancer immunotherapy. Although, under defined experimental conditions, DCs can be generated from myeloid or lymphoid precursors, the di...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(01)02059-2
更新日期：2001-12-01 00:00:00
abstract：:Nucleotide-binding oligomerization domain protein (NOD)1 and NOD2 participate in signaling pathways that detect pathogen-induced processes, such as the presence of peptidoglycan fragments in the host cell cytosol, as danger signals. Recent work suggests that peptidoglycan fragments activate NOD1 indirectly, through ac...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2013.10.009
更新日期：2014-03-01 00:00:00
abstract：:Toll-like receptors (TLRs) are sensors of foreign microbial products, which initiate host defense responses in all multicellular organisms examined to date. They are the target for most adjuvants, are essential for the establishment of memory in T and B cells and provoke inflammation. They program dendritic cells in t...
journal_title：Trends in immunology
pub_type： 传,历史文章,杂志文章,评审
doi：10.1016/j.it.2004.10.005
更新日期：2004-12-01 00:00:00
abstract：:Mammalian group 2 innate lymphoid cells (ILC2s) are responsible for the early production of type 2 cytokines at mucosal barriers upon exposure to allergen. Inflammatory tissue environmental cues can influence ILC2 activity, and this cellular population can be further categorized into subtypes with additional or altern...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2019.10.007
更新日期：2019-12-01 00:00:00
abstract：:Helminth parasites survive through a combination of parasite longevity, repeated re-infection and selective immune suppression to prevent protective Th2 responses. To counteract helminth-induced immunosuppression, and to induce long-term immunological memory, understanding of the multiple regulatory pathways within th...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2012.01.001
更新日期：2012-04-01 00:00:00
abstract：:Immuno-gene therapy can be advantageously performed with nonviral approaches. Genes that encode regulatory cytokines or inflammatory cytokine inhibitors can be delivered intramuscularly and expressed for weeks or months. This type of gene transfer into muscle has been shown to ameliorate several autoimmune diseases an...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(00)01822-6
更新日期：2001-03-01 00:00:00
abstract：:CD45, the leucocyte common antigen, is a haemopoietic cell-specific tyrosine phosphatase. Many isoforms are generated by alternative splicing, but their function remains obscure. The extracellular domain of CD45 is highly polymorphic in all vertebrates. Importantly, human polymorphic variants that alter CD45 isoform e...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2006.01.001
更新日期：2006-03-01 00:00:00
abstract：:In autoimmune disease, a network of diverse cytokines is produced in association with disease susceptibility to constitute the 'cytokine milieu' that drives chronic inflammation. It remains elusive how cytokines interact in such a complex network to sustain inflammation in autoimmune disease. This has presented huge c...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2012.10.003
更新日期：2013-03-01 00:00:00
abstract：:The circadian system ensures the generation and maintenance of self-sustained ~24-h rhythms in physiology that are linked to internal and environmental changes. In mammals, daily variations in light intensity and other cues are integrated by a hypothalamic master clock that conveys circadian information to peripheral ...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2012.08.007
更新日期：2012-12-01 00:00:00
abstract：:There is a growing body of evidence suggesting that bacterial signaling molecules are involved in cross-kingdom communication with eukaryotic cells. Bacterial signaling molecules can enter eukaryotic cells and appear to modulate immune responses to bacterial pathogens. Recently, an enticing study demonstrated that mam...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2004.08.001
更新日期：2004-10-01 00:00:00
abstract：:Immune 'checkpoint' inhibitors can increase the activity of tumor-resident cytotoxic lymphocytes and have revolutionized cancer treatment. Current therapies block inhibitory pathways in tumor-infiltrating CD8+ T cells and recent studies have shown similar programs in other effector populations such as natural killer (...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2018.12.003
更新日期：2019-02-01 00:00:00
abstract：:Toll-like receptors (TLRs) are primordial pathogen-recognition proteins that function as sentinels for the innate immune system. One of the TLR mysteries relates to TLR11, a receptor present in mice, but not humans, and known to recognize uropathogenic Escherichia coli. The first defined ligand for TLR11 has now been ...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2005.08.006
更新日期：2005-10-01 00:00:00
